The efficacy of (Saffron) versus placebo and Fluoxetine in treating depression: a systematic review and meta-analysis.

Depression represents a serious public health concern, imposing a high burden, both in epidemiological and clinical terms. (Saffron) is a herbal remedy that has anti-cancer, anti-oxidant, anti-inflammatory and anti-platelet properties. However, the exact mechanisms of Saffron in treating depression are not yet clear.