Publications by authors named "Fiorella Angelica Valeria Ferraiolo"
Background: Inflammation plays an essential role in the development and complications of atherosclerosis plaques, including acute coronary syndromes (ACS). Indeed, previous reports have shown that within the coronary circulation of ACS patients, several soluble mediators are released. Moreover, it has been demonstrated that endothelial dysfunction might play an important role in atherosclerosis as well as ACS pathophysiology.
View Article and Find Full Text PDFLong-term administration of ranolazine attenuates diastolic dysfunction and adverse myocardial remodeling in a model of heart failure with preserved ejection fraction.
Int J Cardiol
August 2016
Article Synopsis
- The study investigates the effects of ranolazine (RAN) on heart failure with preserved ejection fraction using Dahl salt-sensitive rats, which were put on a high salt diet to induce hypertension.
- Results showed that RAN improved diastolic parameters, reduced mortality, and decreased myocardial hypertrophy by altering signaling pathways and collagen deposition.
- The study concludes that RAN can help mitigate diastolic dysfunction, indicating potential benefits for heart failure management.
Background: The search for compounds able to counteract chemotherapy-induced heart failure is extremely important at the age of global cancer epidemic. The role of SIRT1 in the maintenance of progenitor cell homeostasis may contribute to its cardioprotective effects. SIRT1 activators, by preserving progenitor cells, could have a clinical relevance for the prevention of doxorubicin (DOXO)-cardiotoxicity.
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