Publications by authors named "Fionnuala Johnston"
Article Synopsis
- A study compared appetite regulation among Parkinson's Disease (PD) patients with cognitive impairment (CI), PD patients without CI, and age-matched controls to understand how these factors influence appetite.
- Results showed that PD patients with CI consumed significantly less protein and had altered hormone levels, which were linked to decreased hunger and energy intake.
- The hormones peptide YY (PYY) and glucagon-like peptide 1 (GLP-1) play key roles in appetite control for PD patients, suggesting they are important areas for further research.
Blood-borne factors regulate adult hippocampal neurogenesis and cognition in mammals. We report that elevating circulating unacylated-ghrelin (UAG), using both pharmacological and genetic methods, reduced hippocampal neurogenesis and plasticity in mice. Spatial memory impairments observed in ghrelin-O-acyl transferase-null (GOAT) mice that lack acyl-ghrelin (AG) but have high levels of UAG were rescued by acyl-ghrelin.
View Article and Find Full Text PDFBackground: Urate and homocysteine are potential biomarkers for disease progression in Parkinson's disease (PD). Baseline serum urate concentration has been shown to predict motor but not cognitive decline. The relationship between serum homocysteine concentration and cognitive and motor impairment is unknown.
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