Publications by authors named "Fiona P Galleway"
We describe a novel series of imidazopyridine substituted phenylalanines which are potent VLA-4 antagonists. A wide variety of substituents are tolerated as replacements for the pendant 3-pyridyl ring. A clear structure-activity relationship was identified around the substitution of the 3-amino-cyclobut-2-enone portion of the molecule.
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- Researchers explored new bicyclic heteroaryl ring structures to replace a specific part of the rolipram chemical structure.
- This investigation led to the identification of 8-methoxyquinoline-5-carboxamides.
- These compounds were found to be strong inhibitors of the enzyme phosphodiesterase type 4 (PDE4).
The synthesis and pharmacological profile of a novel series of 7-methoxy-furo[2,3-c]pyridine-4-carboxamides is described. Some of these compounds were found to be potent inhibitors of phosphodiesterase type 4 (PDE4).
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