Expression of the anaphylatoxin receptors C3aR and C5aR is increased in fatal asthma.

Background: The mechanisms leading to death from asthma are not completely understood. Recent studies suggest the involvement of the anaphylatoxins C3a and C5a, generated during complement activation, and their receptors C3aR and C5aR in the pathogenesis of asthma.

Objective: The aim of our study was to investigate the expression of C3aR and C5aR in fatal asthma.