Publications by authors named "Fiona Hoar"
Article Synopsis
- * Analysis of 93 untreated IBC samples showed that lower-grade tumors had fewer CD4+ cells but more FOXP3+ cells; higher CD20+ cell levels were linked to better chemotherapy responses.
- * The study found distinct immune cell patterns in various subtypes of IBC, suggesting that understanding these patterns could improve therapies and contribute to developing immunotherapy strategies.
The immune microenvironment in inflammatory breast cancer (IBC) is poorly characterised, and molecular and cellular pathways that control accumulation of various immune cells in IBC tissues remain largely unknown. Here, we discovered a novel pathway linking the expression of the tetraspanin protein CD151 in tumour cells with increased accumulation of macrophages in cancerous tissues. It is notable that elevated expression of CD151 and a higher number of tumour-infiltrating macrophages correlated with better patient responses to chemotherapy.
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