Publications by authors named "Fiona Foad"
Research Question: Does using an objective time-lapse imaging algorithm (TLIA) after IVF relate to conventional morphological assessment of human blastocysts as a prognosticator for live birth?
Design: Prospective use of a TLIA to select embryos in multicentre IVF clinics all using the same strictly controlled laboratory protocols. Each blastocyst was given a ranking from A to D, with the highest rank preferred for fresh transfer. This ranking was retrospectively compared with a given morphological score, which was blinded to the TLIA rank; all embryos were cultured under the same conditions.
Article Synopsis
- The research investigates if embryos, specifically blastocysts, can be ranked using morphokinetic-based algorithms to predict the likelihood of live births.
- A study analyzed 781 single blastocyst transfers and found that higher-ranked embryos (A) have significantly better odds of resulting in live births compared to lower ranks (B, C, D), with a clear drop in success from rank A (52.5%) to rank D (13.2%).
- The findings suggest that using time-lapse imaging to assess blastocysts may be more effective for predicting live births than traditional methods based on embryo morphology alone.