Publications by authors named "Fiona Fitzgerald"
Large ribosomal subunit precursors (pre-LSUs) are primarily synthesized in the nucleolus. At an undetermined step in their assembly, they are released into the nucleoplasm. Structural models of yeast pre-LSUs at various stages of assembly have been collected using cryo-EM.
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- Nascent polypeptide chains exit the ribosome via the nascent polypeptide exit tunnel (NPET), which is influenced by specific ribosomal proteins, highlighting the complexity of translation and ribosome assembly.
- The protein eL39 plays a crucial role in the construction of the NPET, facilitating both early stages of pre-60S assembly and proper protein folding during translation.
- Research indicates that eL39 is involved in alternative pathways of ribosome assembly, suggesting similarities with bacterial ribosomal subunit biogenesis.
Waiting for infected hip revision surgery; exploring patient and families' experience of waiting (PREWs).
Int J Orthop Trauma Nurs
February 2022
Introduction: As a tertiary center for complex orthopedic surgery, evaluating current practice is vital to enhance pathways of care. A vital element of this is to understand service users' perspectives and experiences, yet little research to date has explored experiences of waiting for surgery in this cohort.
Methods: The aim of this mixed methods study was to understand patients' and families' experiences of waiting for hip revision surgery for joint infection and their perceptions of its impact on their quality of life.
Article Synopsis
- Viral RNA-dependent RNA polymerases (RdRps) are crucial targets for broad-spectrum antiviral drugs, and a specific compound, T-1106 triphosphate, influences their function by causing delays in RNA synthesis.
- Using magnetic tweezers, researchers found that the RdRp of enterovirus A-71 utilizes a "backtracked" state to facilitate processes like copy-back RNA synthesis and homologous recombination during viral replication.
- The study indicates that pyrazine-carboxamide ribonucleotides enhance these processes without causing harmful mutations, suggesting they can promote the creation of defective viral genomes, presenting a new potential for antiviral therapies.
Chloroviruses are large, plaque-forming, dsDNA viruses that infect chlorella-like green algae that live in a symbiotic relationship with protists. Chloroviruses have genomes from 290 to 370 kb, and they encode as many as 400 proteins. One interesting feature of chloroviruses is that they encode a potassium ion (K) channel protein named Kcv.
View Article and Find Full Text PDFBackground: The management of complex orthopedic infections usually includes a prolonged course of intravenous antibiotic agents. We investigated whether oral antibiotic therapy is noninferior to intravenous antibiotic therapy for this indication.
Methods: We enrolled adults who were being treated for bone or joint infection at 26 U.
Background: Alemtuzumab is a highly effective treatment for relapsing-remitting multiple sclerosis (MS) but requires ongoing pathology monitoring for autoimmune adverse effects. The Alemtuzumab in MS Safety Systems (AMS3) study evaluated the implementation of an automated pathology-monitoring system.
Objectives: To develop an efficient automated clinical decision support system (CDSS) to electronically prompt and track pathology collection and to provide prescribers and patients with customised alerts of abnormal results for identified risks.