Publications by authors named "Fiona D Ehrich"
Article Synopsis
- - Recent advancements in multiplexed tissue imaging are improving our understanding of tumor microenvironments, which could better inform treatment responses and disease progression studies.
- - Despite its popularity, current analysis methods face challenges such as high computational demands and a lack of consistent strategies for understanding spatial features in images as diseases progress.
- - The newly introduced spatial topic model effectively integrates cell type and spatial data, demonstrating strong performance in identifying significant spatial topics and tracking changes during disease progression, making it efficient for large-scale tissue imaging analyses.
Purpose: The Adaptively Dosed ImmunoTherapy Trial (ADAPT-IT;NCT03122522) investigated adaptive ipilimumab discontinuation in melanoma based on early radiographic assessment. Initial findings indicated similar effectiveness compared with conventional nivolumab-ipilimumab (nivo-ipi). Exploratory biomarker analyses and final clinical results are now reported.
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