Publications by authors named "Fiona C Roth"
Chem Biol Interact
August 2013
Article Synopsis
- Amiodarone (AM) is a powerful anti-dysrhythmic drug that can lead to serious lung damage, known as amiodarone-induced pulmonary toxicity (AIPT), due to lung cell death and subsequent inflammation.
- Its main metabolite, desethylamiodarone (DEA), is even more toxic and may work together with AM to increase lung toxicity.
- The study found that both AM and DEA cause lung cell death in a dose-dependent manner, with different mechanisms, and their combined effects are additive, suggesting a significant clinical concern regarding their interaction that can contribute to AIPT.
