Extended 72-hour patency capsule protocol improves functional patency rates in high-risk patients undergoing capsule endoscopy.

Background: Capsule endoscopy (CE) is a pivotal diagnostic tool for gastrointestinal (GI) disorders, yet capsule retention poses a significant risk, especially in patients with known risk factors. The patency capsule (PC) helps assess the functional patency of the GI tract to mitigate this risk. However, the standard 28-hour protocol for confirming patency often results in high false-positive rates, unnecessarily excluding many patients from undergoing diagnostic CE.

HLA-DQA1*05 Allele Carriage and Anti-TNF Therapy Persistence in Inflammatory Bowel Disease.

Introduction: Carriage of the HLA-DQA1*05 allele is associated with development of antidrug antibodies (ADAs) to antitumor necrosis factor (anti-TNF) therapy in patients with Crohn's disease. However, ADA is not uniformly associated with treatment failure. We aimed to determine the impact of carriage of HLA-DQA1*05 allele on outcome of biologic therapy evaluated by drug persistence.

: High dose amoxicillin does not improve primary or secondary eradication rates in an Irish cohort.

Background: () eradication rates have fallen globally, likely in large part due to increasing antibiotic resistance to traditional therapy. In areas of high clarithromycin and metronidazole resistance such as ours, Maastricht VI guidelines suggest high dose amoxicillin dual therapy (HDADT) can be considered, subject to evidence for local efficacy. In this study we assess efficacy of HDADT therapy for eradication in an Irish cohort.

Cloud technology and capsule endoscopy: A single-center users' experience of remote online video analysis and reporting.

Telemedicine has progressed significantly in recent years, with newer, more integrated information technology systems improving healthcare delivery. The development of the world's first cloud-based capsule platform could allow safe and timely virtual analysis of videos from a network of linked hospital centers. We aimed to assess the efficacy of Medtronic's PillCam Remote Reader System.

Capsule endoscopy with artificial intelligence-assisted technology: Real-world usage of a validated AI model for capsule image review.

Capsule endoscopy is a time-consuming procedure with a significance error rate. Artificial intelligence (AI) can potentially reduce reading time significantly by reducing the number of images that need human review. An OMOM Artificial Intelligence-enabled small bowel capsule has been recently trained and validated for small bowel capsule endoscopy video review.

Patency testing improves capsule retention rates but at what cost? A retrospective look at patency testing.

Capsule retention is one of the major complications of capsule endoscopy, which range from 2.1 to 8.2% depending on the indication.

Score reproducibility and reliability in differentiating small bowel subepithelial masses from innocent bulges.

Aims: The primary aim of this study was to assess the reliability, intra- and inter-observer variation of the SPICE, Mucosal protrusion angle (MPA) and SHYUNG scores in differentiating a subepithelial mass (SEM) from a bulge.

Methods: This retrospective multicentre study analysed the 3 scores, radiological studies, enteroscopy and/or surgical findings.

Results: 100 patients with a potential SEM (mean age 57.

Addition of castor oil as a booster in colon capsule regimens significantly improves completion rates and polyp detection.

Background: Incomplete excretion rates are problematic for colon capsule endoscopy (CCE). Widely available booster regimens are suboptimal. Recently published data on one day preparation CCE protocol using castor oil appeared effective.

Small-Bowel Capsule Endoscopy-Optimizing Capsule Endoscopy in Clinical Practice.

The small bowel is the longest organ within the gastrointestinal tract. The emergence of small bowel capsule endoscopy (SBCE) over the last 20 years has revolutionized the investigation and diagnosis of small bowel pathology. Its utility as a non-invasive and well-tolerated procedure, which can be performed in an outpatient setting, has made it a valuable diagnostic tool.