Genetic Link Between Gender Dysphoria and Sex Hormone Signaling.

Context: There is a likely genetic component to gender dysphoria, but association study data have been equivocal.

Objective: We explored the specific hypothesis that gender dysphoria in transgender women is associated with variants in sex hormone-signaling genes responsible for undermasculinization and/or feminization.

Design: Subject-control analysis included 380 transgender women and 344 control male subjects.

Assessing patient satisfaction with a multidisciplinary gender dysphoria clinic in Melbourne.

Objectives: The Gender Dysphoria Clinic in Melbourne, Australia, assessed patient outcome by focusing on patients' subjective evaluation of the healthcare services they received through the clinic.

Methods: A satisfaction survey, which was previously used in two established gender clinics in the US and UK, was adapted and then administered to consecutive patients who attended the Gender Dysphoria Clinic during a 1-month period.

Results: A total of 127 surveys were available for analysis: 88% of patients reported being satisfied with the services they received.

Genital self-mutilation by radio-frequency in a male-to-female transsexual.

We report the case of a male-to-female transgender individual who inflicted radio-frequency injuries to her testicles in an attempt to damage them. Important consideration should be given by medical practitioners when they are faced with an individual who believes he or she is transgender. A sympathetic approach should be taken and a referral made to a clinician or service experienced in dealing with transgender patients.