Successful pregnancy rates amongst patients undergoing ovarian tissue cryopreservation for non-malignant indications: A systematic review and meta-analysis.

Background: Ovarian tissue cryopreservation (OTC) is a fertility preservation method that has been clinically applied for almost 30 years. Studies specifically evaluating patients presenting with non-malignant indications for OTC and their subsequent pregnancy rates are limited.

Objective: To summarise the evidence on the rates of successful pregnancy amongst women who have undergone OTC for non-malignant indications.

The Edmonton Classification System for Cancer Pain in Patients with Bone Metastasis: a descriptive cohort study.

Purpose: We describe the prevalence of the Edmonton Classification System for Cancer Pain (ECS-CP) features in patients with bone metastasis and cancer-induced bone pain (CIBP) and the relationship between ECS-CP features, pain intensity, and opioid consumption.

Methods: We assessed ECS-CP features and recoded pain mechanisms and opioid use in adult patients with bone metastasis. Validated measures were used to assess pain intensity, incident pain, psychological distress, addictive behavior, and cognition.

Permanent Tooth Agenesis and Associated Dental Anomalies among Orthodontically Treated Children.

(1) Background: Tooth agenesis is one of the most common developmental dental anomalies often affecting the maxillary incisors area and premolar regions. (2) Purpose: The aim of this study was to assess the prevalence and distribution of permanent tooth agenesis and the associated dental abnormalities among orthodontically treated children. (3) Materials and Methods: This study was carried out utilizing 3000 pretreatment records of children who underwent orthodontic treatment, 1780 (59%) females and 1220 (41%) males, aged 10-25 years (mean age 15 years).

Targeting BCL-XL in fibrolamellar hepatocellular carcinoma.

Fibrolamellar hepatocellular carcinoma (FLC) is a rare and often lethal liver cancer with no proven effective systemic therapy. Inhibition of the antiapoptotic protein BCL-XL was found to synergize with a variety of systemic therapies in vitro using cells dissociated from patient-derived xenografts (PDX) of FLC or cells dissociated directly from surgical patient resections. As BCL-XL is physiologically expressed in platelets, prior efforts to leverage this vulnerability in other cancers have been hampered by severe thrombocytopenia.

Activity Across the Lateral Somitic Frontier Regulates Development of the Mouse Sternum.

The skeletal system derives from multiple embryonic sources whose derivatives must develop in coordination to produce an integrated whole. In particular, interactions across the lateral somitic frontier, where derivatives of the somites and lateral plate mesoderm come into contact, are important for proper development. Many questions remain about genetic control of this coordination, and embryological information is incomplete for some structures that incorporate the frontier, including the sternum.

Patterns of Cone-Beam Computed Tomography (CBCT) Utilization by Various Dental Specialties: A 4-Year Retrospective Analysis from a Dental and Maxillofacial Specialty Center.

The study aimed to analyze the uses of cone-beam computed tomography (CBCT) in the diagnosis and treatment in various dental specialties. This 4-year cross-sectional study analyzed the records of 1409 individuals who underwent a CBCT at the Oral and Maxillofacial Center at Sheba Medical Center, Israel. The average age of the patients was 27.

Dental Anomalies' Characteristics.

The aim of this study was to characterize dental anomalies. The pretreatment records (photographs and radiographs) of 2897 patients (41.4% males and 58.

HOXA5 Participates in Brown Adipose Tissue and Epaxial Skeletal Muscle Patterning and in Brown Adipocyte Differentiation.

Brown adipose tissue (BAT) plays critical thermogenic, metabolic and endocrine roles in mammals, and aberrant BAT function is associated with metabolic disorders including obesity and diabetes. The major BAT depots are clustered at the neck and forelimb levels, and arise largely within the dermomyotome of somites, from a common progenitor with skeletal muscle. However, many aspects of BAT embryonic development are not well understood.

Canine Transposition - Prevalence, Distribution and Treatment Considerations among Orthodontic Patients.

Unlabelled: Tooth transposition is a relatively rare dental anomaly of interchange in position of two adjacent teeth.

Aim: To determine the prevalence and distribution of canine transposition in a sample of orthodontic patients and present treatment alternatives and outcome.

Study Design: The records of 3000 consecutively treated orthodontic patients from a university clinic were surveyed to detect canine transposition in both dental arches.

Prevalence and Characteristics of Supernumerary Teeth in Israeli Orthodontic Patients.

Background: Supernumerary teeth are one of the most common anomalies in the human dentition, found most frequently in the maxillary anterior region causing impaction or displacement of the adjacent permanent teeth.

Aim: The purpose of this retrospective study was to determine the prevalence and characteristics of supernumerary teeth in orthodontically treated patients.

Study Design: Pre-treatment facial and intraoral photographs, study models, panoramic and periapical radiographs of 3,000 consecutively treated orthodontic patients (mean age 12.

Agenesis of Permanent Canines in Orthodontic Patients: Prevalence, Location, Treatment Options and Outcomes.

Tooth agenesis is one of the most common anomalies of the human dentition, found most often in the maxillary anterior region and in the mandibular and maxillary premolar regions. Little information is available on the prevalence and distribution of permanent canine agenesis. The purpose of this retrospective study was to evaluate the prevalence and distribution of permanent canine agenesis in orthodontic patients and describe treatment options and outcomes.

Supernumerary Teeth in the Maxillary Anterior Region: The Dilemma of Early Versus Late Surgical Intervention.

Supernumerary teeth are the most common developmental dental anomalies in the maxillary anterior region causing interference to the developing permanent incisors resulting in poor dental and facial esthetics. Two different opinions regarding the timing for surgical removal of the supernumerary teeth are presented. In this case report, three brothers with supernumerary teeth in the maxillary anterior region are presented, their surgical and orthodontic management and outcome are discussed.

Mandibular Symmetrical Bilateral Canine-Lateral Incisors Transposition: Its Early Diagnosis and Treatment Considerations.

Bilateral mandibular tooth transposition is a relatively rare dental anomaly caused by distal migration of the mandibular lateral incisors and can be detected in the early mixed dentition by radiographic examination. Early diagnosis and interceptive intervention may reduce the risk of possible transposition between the mandibular canine and lateral incisor. This report illustrates the orthodontic management of bilateral mandibular canine-lateral incisor transposition.

Fused and Geminated Permanent Maxillary Central Incisors: Prevalence, Treatment Options, and Outcome in Orthodontic Patients.

Purpose: Developmental disturbances during tooth formation may cause abnormalities in tooth size and shape, resulting in poor dental and facial esthetics. The purpose of this study was to evaluate the prevalence of fused/geminated teeth in the maxillary anterior region of orthodontically treated patients, and present treatment options and their outcome.

Methods: Pre- and post-treatment facial and intraoral photographs, study models, and panoramic and periapical radiographs of 574 consecutively treated patients (mean age: 13.

Conservative orthodontic treatment for skeletal open bite associated with amelogenesis imperfecta.

Amelogenesis imperfect (AI) is a hereditary dental condition that affects tooth enamel, resulting in small and discolored teeth, tooth sensitivity, poor esthetics, and anterior open bite associated with severe discrepancy in the vertical relation of the jaws. Treatment can be complex and includes an interdisciplinary approach involving orthodontics, oral surgery, and restorative therapy. The purpose of this report is to describe the case of a 12-year-old girl with AI and severe open bite who received conservative, non-surgical therapy that led to good functional occlusion and acceptable dental and facial esthetics.

Health-related fitness of American Indian youth.

Unlabelled: A physically fit lifestyle is important for American Indian (AI) youth who are at risk for hypokinetic diseases, particularly type 2 diabetes. Some evidence exists on the physical activity patterns of AI youth, but there is little information on their health-related fitness.

Purpose: The purpose of this study was to describe the health-related fitness levels of youth living in an AI community.

Mandibular second molar impaction. Part I: Genetic traits and characteristics.

Introduction: Detection of mandibular second molar (MM2) impaction is imperative for orthodontic diagnosis and treatment. In this study, we examined a possible genetic trait in MM2 impaction in 2 populations and defined distinctive characteristics.

Methods: Initial panoramic radiographs of patients of Israeli (n = 3500) and Chinese-American (n = 3000) origin, aged 11 to 15 years, were examined.

[Do temporomandibular disorders really exist?].

Temporomandibular Disorders (TMD) is a collective term embracing a number of clinical problems that involve the muscles of mastication, the temporomandibular joint (TMJ) and associated structures or both. This group of disorders has been identified as the chief cause of pain, which is not of dental origin, in the orofacial area, and is defined as a subgroup in the category of musculoskeletal disorders. These disorders impair the quality of life of those suffering from them due to the extent of the pain and the chronic nature of its symptoms.

Determination of platinum in serum and ultrafiltrate by flameless atomic absorption spectrophotometry.

A graphite furnace atomic absorption spectrophotometric assay, capable of accurately determining nanogram amounts of platinum in serum and ultrafiltrate, was developed. A sample serum or ultrafiltrate was acidified with nitric acid and heated to destroy the protein-platinum bond. A measured excess of ammonium 1-pyrrolidinedithiocarbamate was added, and the platinum complex was extracted into isopropylacetone.

Systemic chemotherapy for a primary germ cell tumor of the brain: a pharmacokinetic study.

Systemic administration of most chemotherapeutic agents has been assumed to be ineffective in the treatment of primary and metastatic brain tumors because these agents fail to cross the intact blood-brain barrier. However, agents which fail to penetrate the intact blood-brain barrier may penetrate it under conditions which include the presence of tumor in the central nervous system (CNS) and prior CNS irradiation. This paper reports the results of pharmacokinetic studies of bleomycin, cisplatin, and vinblastine in the CNS of a patient with a primary germ cell tumor of the brain who had received prior radiotherapy.

Anthracycline assay by high-pressure liquid chromatography.

A general method of analysis of anthracycline concentrations was developed. Drug is extracted from plasma with organic solvent and separated from metabolites by high-pressure liquid chromatography on an aminocyanosilica column. Detection and quantitation are by the endogenous fluorescence of compounds having an intact tetracyclic ring structure.