Three-dimensional ultrasound for the measurement of choroidal melanomas.

Objective: To evaluate the reliability of 3-dimensional ultrasound (3D-US) for the measurement of choroidal melanomas.

Design: Retrospective case series.

Participants: Forty-two consecutive cases of choroidal melanoma imaged with 3D-US.

Plaque radiation therapy for malignant melanoma of the iris and ciliary body.

Purpose: To report on plaque radiation therapy for malignant melanomas involving the iris and ciliary body.

Methods: Twenty-two eyes (22 patients) with anterior uveal melanomas were treated with (103)Pd ophthalmic plaque radiation therapy. Transillumination and ultrasonography were used to evaluate ciliary body involvement and posterior iris extension.

Chemotherapy for eye cancer.

Chemotherapy has been used to treat a multitude of eye cancers. We attempted to review the role of chemotherapy in the treatment of ocular, adnexal, and orbital malignancies by conducting an extensive search of the medical literature. Unfortunately, the published reports typically contain few patients with limited follow-up, precluding definitive recommendations.

Iris and ciliary body melanomas: ultrasound biomicroscopy with histopathologic correlation.

Objective: To correlate ultrasound biomicroscopic images of iris and ciliary body melanomas with their histopathologic features.

Methods: Ultrasound biomicroscopy was performed in 3 cases of iris melanoma and in 3 cases of ciliary body melanoma. Cross-sectional ultrasound biomicroscopic images were compared with findings from clinical examination and light microscopy to evaluate associations between their histopathologic, surface, and internal ultrasound characteristics.

Tumour location affects the incidence of cataract and retinopathy after ophthalmic plaque radiation therapy.

Aim: To examine how tumour location affects ocular morbidity after ophthalmic plaque radiotherapy for uveal melanoma.

Methods: 69 eyes were irradiated and followed for a mean 42 months. There were 23 anterior uveal melanomas and 46 were posterior to the equator.

Topical mitomycin chemotherapy for conjunctival malignant melanoma and primary acquired melanosis with atypia: clinical experience with histopathologic observations.

Objectives: To clinically evaluate topical mitomycin chemotherapy in patients with diffuse, multifocal, or recurrent primary acquired melanosis with atypia and/or conjunctival malignant melanoma and to histopathologically study ocular tissue samples obtained before and after treatment.

Methods: Chemotherapy with topical mitomycin, 0.04% 4 times daily, was administered for 28 days as the primary and only treatment in 7 patients (after biopsy) and for 7 days as adjuvant therapy to excision and cryotherapy in 5 patients.

Enucleation.

The three most common indications for enucleation are intraocular malignancy, trauma, and a blind, painful eye. Recommending enucleation is one of the most difficult therapeutic decisions in ophthalmology. In some cases of malignancy, cryotherapy, laser photocoagulation, diathermy, chemotherapy, and radiation therapy may be viable alternatives to surgery.

Chemotherapy for retinoblastoma: a current topic.

Retinoblastoma is the most common primary intraocular tumour in children, with an incidence of 1 in 15,000 live births. Treatment strategies for retinoblastoma have gradually evolved over the past few decades. There has been a trend away from enucleation (removal of the eye) and external beam radiation therapy toward focal 'conservative' treatments.

Differential diagnosis of anterior segment cysts by ultrasound biomicroscopy.

Background: To describe the ultrasound biomicroscopic (UBM) features of anterior segment cysts.

Design: A retrospective case series.

Participants: One hundred eighteen eyes with anterior segment cysts examined by UBM at The New York Eye and Ear Infirmary between August 1992 and November 1997 were included in this study.

Diode-light transillumination for ophthalmic plaque localization around juxtapapillary choroidal melanomas.

Purpose: An evaluation of plaque-mounted diode-light transillumination (DLT) for localization of episcleral plaques beneath juxtapapillary tumors.

Methods And Materials: Two patients scheduled for radiotherapy for juxtapapillary melanomas were offered DLT as an additional method of ophthalmic plaque localization. Plaques were constructed by affixing 4 non-heat producing, light-emitting diodes with their apertures flush with the episcleral outer surface of the plaque's rim.

Radiation therapy for age-related macular degeneration.

Neovascular age-related macular degeneration is the most common cause of severe irreversible blindness in the Western world in people older than age 50. Laser photocoagulation is the only proven treatment for this disease; however, fewer than 20% of patients are eligible for this treatment because the majority of choroidal neovascularization membranes are not visible by ophthalmoscopy or angiography. In addition, many patients elect not to undergo this treatment because laser treatment of subfoveal neovascular membranes results in immediate and permanent central visual loss.

Palladium-103 plaque radiotherapy for choroidal melanoma: results of a 7-year study.

Objective: To describe the first clinical experience with palladium-103 (103Pd) ophthalmic plaque radiotherapy for choroidal melanoma.

Design: Phase-I (nonrandomized) clinical trial.

Participants: Eighty patients with uveal melanomas were diagnosed by clinical examination, found to be negative for metastatic disease, and offered 103Pd radioactive plaque treatment.

Plaque-mounted diode-light transillumination for localization around intraocular tumors.

Objective: To evaluate the usefulness of plaque-mounted diode-light transillumination (DLT) for the localization of episcleral plaques around intraocular tumors.

Methods: A clinical case series was performed to create, evaluate, and modify diode-light plaque construction, application, and imaging. Eight patients with choroidal melanoma were offered DLT as an additional method of ophthalmic plaque localization.

Ophthalmic plaque radiotherapy for age-related macular degeneration associated with subretinal neovascularization.

Purpose: To evaluate ophthalmic plaque radiotherapy for the treatment of subretinal neovascularization associated with age-related macular degeneration.

Methods: In a prospective phase I clinical trial, we treated 23 patients (23 eyes) with ophthalmic plaque radiotherapy for subfoveal exudative macular degeneration. Palladium 103 ophthalmic plaque brachytherapy was delivered to a retinal apex dose of 1,250 to 2,362 cGy (rad).

Anterior segment implantation cysts. Ultrasound biomicroscopy with histopathologic correlation.

Objective: To correlate the clinical, histopathologic, and ultrasound biomicroscopic characteristics of anterior segment implantation cysts.

Methods: We performed a retrospective review of 7 cases of secondary anterior segment implantation cysts. We reviewed the clinical history, visual acuity, clinical findings, and ultrasound biomicroscopic characteristics in all cases.

Three-dimensional ultrasonography of choroidal melanoma: extrascleral extension.

Purpose: To describe the results of three-dimensional ultrasonography used to evaluate extrascleral extension of a choroidal melanoma.

Methods: Case report. The three-dimensional ultrasound system uses a 10-MHz B-mode transducer combined with a motorized rotating holder.

Ultrasound biomicroscopy in the diagnosis and management of anterior segment tumors.

Background: High-frequency ultrasound biomicroscopy has allowed eye care specialists to evaluate posterior extension of anterior segment tumors. This article evaluates the role of ultrasound biomicroscopy for the diagnosis and management of anterior segment tumors.

Methods: Fourteen patients with anterior segment tumors were selected for evaluation.

Topical mitomycin C chemotherapy for conjunctival melanoma and PAM with atypia.

Aim: To evaluate topical mitomycin C (MMC) chemotherapy in the treatment of conjunctival melanoma and primary acquired melanosis with atypia.

Methods: In a phase I clinical trial, 10 patients with conjunctival melanoma and/or primary acquired melanosis with atypia were treated with topical MMC 0.04% four times daily.

Three-dimensional ultrasonography of choroidal melanoma: localization of radioactive eye plaques.

Objective: To evaluate the use of 3-dimensional (3D) ultrasonography for the localization of episcleral eye plaques during the treatment of choroidal melanomas.

Methods: A series of 13 patients with choroidal melanoma were treated with radioactive palladium 103 seeds affixed into gold eye plaques. During surgery, 3D ultrasonography was performed with a commercially available system to evaluate the relative position of radioactive plaques secured beneath their intraocular tumors.