The potency of ethyl acetate fraction of cempedak (Artocarpus champeden) leaves in attenuating the nephrotoxic effect in gentamicin-piroxicam-induced rat models.

Background: Nephrotoxicity is a condition characterized by a decline in kidney function due to the toxic effects of medications and substances, such as the nephrotoxic antibiotic gentamicin. Artocarpus champeden is a traditional medicinal plant that is commonly found in Indonesia.

Objective: This study aims to evaluate the potential of the ethyl acetate fraction of Artocarpus champeden leaves (FEC) in improving kidney function in an animal model of nephrotoxicity induced by gentamicin and piroxicam.