Publications by authors named "Filomena Manjate"
Article Synopsis
- Enteric viruses are the main cause of diarrhea in children under 5, with rotavirus being a well-researched culprit in Mozambique, though other viruses lack data post-vaccine.
- The study investigated the prevalence of norovirus GI and GII, adenovirus 40/41, astrovirus, and sapovirus in children with varying severity of diarrhea before and after the introduction of the rotavirus vaccine.
- Results showed that all viruses, except norovirus GI, were detected more frequently after the vaccine's introduction, highlighting the importance of ongoing monitoring for these viruses to improve disease prevention strategies.
Mozambique introduced the rotavirus vaccine (Rotarix®; GlaxoSmithKline Biologicals, Rixensart, Belgium) in 2015, and since then, the Centro de Investigação em Saúde de Manhiça has been monitoring its impact on rotavirus-associated diarrhea and the trend of circulating strains, where G3P[8] was reported as the predominant strain after the vaccine introduction. Genotype G3 is among the most commonly detected Rotavirus strains in humans and animals, and herein, we report on the whole genome constellation of G3P[8] detected in two children (aged 18 months old) hospitalized with moderate-to-severe diarrhea at the Manhiça District Hospital. The two strains had a typical Wa-like genome constellation (I1-R1-C1-M1-A1-N1-T1-E1-H1) and shared 100% nucleotide (nt) and amino acid (aa) identities in 10 gene segments, except for VP6.
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- The study assessed the impact of the Rotarix® rotavirus vaccine in Mozambique, focusing on its effect on hospitalizations due to childhood gastroenteritis after its introduction in September 2015.
- Findings showed a significant decrease in the prevalence of acute gastroenteritis from 19% pre-vaccine to 10% post-vaccine, preventing 40% of expected cases overall and 84% of lab-confirmed rotavirus cases in infants.
- The incidence of rotavirus was also drastically lower post-vaccination, with an 11.8-fold decrease, most notably in infants, highlighting the vaccine's important role in protecting vulnerable populations from severe diarrhea and related hospitalizations.
Mozambique introduced monovalent rotavirus vaccine (Rotarix®) in September 2015. We evaluated the effectiveness of Rotarix® under conditions of routine use in Mozambican children hospitalized with acute gastroenteritis (AGE). A test negative case-control analysis was performed on data collected during 2017−2019 from children <5 years old, admitted with AGE in seven sentinel hospital sites in Mozambique.
View Article and Find Full Text PDFGroup A rotaviruses remain the leading cause of diarrhoea in children aged <5 years. Mozambique introduced rotavirus vaccine (Rotarix) in September 2015. We report rotavirus genotypes circulating among symptomatic and asymptomatic children in Manhiça District, Mozambique, pre- and post-vaccine introduction.
View Article and Find Full Text PDFStrengthening tuberculosis diagnosis is an international priority and the advocacy for multi-disease testing devices raises the possibility of improving laboratory efficiency. However, the advantages of centralized platforms might not translate into real improvements under operational conditions. This study aimed to evaluate the field use of the Abbott RealTime MTB (RT-MTB) and Xpert MTB/RIF assays, in a large cohort of HIV-positive and TB presumptive cases in Southern Mozambique.
View Article and Find Full Text PDFEnterocytozoon bieneusi is a human pathogen with a broad range of animal hosts. Initially, E. bieneusi was considered an emerging opportunistic pathogen in immunocompromised, mainly HIV-infected patients, but it has been increasingly reported in apparently healthy individuals globally.
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