Evaluation of a novel oxiconazole nitrate formulation: The thermosensitive gel.

Superficial fungal infections caused by species are common skin diseases. Therefore, this study aimed to develop a new formulation containing oxiconazole nitrate, which is an azole group derivative for antifungal treatment, as a thermosensitive gel since there has been no literature study until now. MIC value of the novel thermosensitive formulation against three species was calculated and time-dependent antifungal activity analysis was performed.

Effects of silibinin and ethanol on skeletal muscle ischemia-reperfusion injury.

Purpose: To investigate the potential beneficial effect of silibinin in ischemia-reperfusion injury (IRI) of skeletal muscle.

Methods: Under urethane anesthesia, four experimental groups were established in Balb/c mice: I) Sham-control, II) IRI (Tourniquet-induced) (2+1 h), III) IRI+ethanol (10%), and IV) IRI+silibinin (50 mg/kg/IP). The viability of muscle (left) was evaluated by the triphenyltetrazolium chloride dye method and calculated as the percentage of the contralateral control muscle (right).

The activity of adenosine deaminase and oxidative stress biomarkers in scraping samples of acne lesions.

Acne vulgaris is one of the most common dermatological diseases, and its pathogenesis is multifactorial. Although there are some reports about role of oxidative stress biomarkers in blood, serum, plasma in the pathogenesis of acne, there has been no report about oxidative stress biomarkers in scraping samples. For this reason, the aim of our study is to determine the role of oxidative stress biomarkers and adenosine deaminase (ADA) in scraping samples of acne lesion and to determine a possible link with the clinical severity.

Elevation of both reactive oxygen species and antioxidant enzymes in vein tissue of infertile men with varicocele.

Objective: To compare reactive oxygen species (ROS) and antioxidants in internal spermatic vein tissue of men with varicocele and a control group with inguinal hernia. Also to compare the levels of oxidants and antioxidants in infertile and fertile men with varicocele.

Patients And Methods: 48 varicocele patients and 12 non-varicocele inguinal hernia patients participated in this study.

Plasma selenium, zinc, copper and lipid levels in postmenopausal Turkish women and their relation with osteoporosis.

It has been shown that the trace elements and lipids play role in the growth, development and maintenance of bones. We aimed to investigate serum selenium (Se), zinc (Zn), copper (Cu) and lipid (total cholesterol, triglyceride (TG), high density lipoprotein-cholesterol, low-density lipoprotein-cholesterol) levels in postmenopausal women with osteoporosis, osteopenia and in healthy controls, and to determine the relationship between Se, Zn, Cu and lipid parameters and bone mineral density (BMD). The study included 107 postmenopausal women; 35 healthy (group 1), 37 osteopenic (group 2) and 35 osteoporotic (group 3).