Publications by authors named "Filippus I Tshavuka"
TAL1 T-cell acute lymphoblastic leukemia (T-ALL) is a distinct subtype of leukemia with poor outcomes. Through the cooperation of co-activators, including RUNX1, GATA3, and MYB, the TAL1 oncoprotein extends the immature thymocytes with autonomy and plays an important role in the development of T-ALL. However, this process is not yet well understood.
View Article and Find Full Text PDF[Potential Oncogenic Role of Genes in PLC Family on T-ALL Cell Lines by Suppression of Apoptosis].
Zhongguo Shi Yan Xue Ye Xue Za Zhi
August 2023
Article Synopsis
- The study investigates how the phospholipase C (PLC) family contributes to the development and progression of acute T lymphoblastic leukemia (T-ALL).
- Methods included analyzing cell death in T-ALL cells after using PLC inhibitors and assessing the influence of PLC expressions on patient survival using various statistical analyses.
- Results indicated that certain T-ALL cell lines were sensitive to PLC inhibitors, while others were resistant, and high expression of specific PLC genes was linked to poor patient prognosis, suggesting these genes could be potential targets for therapy.
Background: The role of pathogen-mediated febrile illness in sub-Saharan Africa is receiving more attention, especially in Southern Africa where four countries (including Namibia) are actively working to eliminate malaria. With a high concentration of livestock and high rates of companion animal ownership, the influence of zoonotic bacterial diseases as causes of febrile illness in Namibia remains unknown.
Methodology/principal Findings: The aim of the study was to evaluate exposure to Coxiella burnetii, spotted fever and typhus group rickettsiae, and Bartonella henselae using IFA and ELISA (IgG) in serum collected from 319 volunteer blood donors identified by the Blood Transfusion Service of Namibia (NAMBTS).