High Plasma Concentration of Apolipoprotein C-III Confers an Increased Risk of Cerebral Ischemic Events on Cardiovascular Patients Anticoagulated With Warfarin.

Introduction: Apolipoprotein C-III (Apo CIII) is a crucial regulator of triglyceride-rich lipoproteins (TRLs) and influences the risk of cardiovascular diseases. High levels of Apo CIII have been also associated with cerebrovascular events and earlier works showed procoagulant effects of Apo CIII. The main aim was to assess whether the plasma concentration of Apo CIII could confer an increased risk of cerebral ischemic events in anticoagulated patients at high-risk of cardioembolism.

Basophil Blood Cell Count Is Associated With Enhanced Factor II Plasma Coagulant Activity and Increased Risk of Mortality in Patients With Stable Coronary Artery Disease: Not Only Neutrophils as Prognostic Marker in Ischemic Heart Disease.

Background White blood cell count, which is inexpensive and widely available in clinical practice, has been proposed to provide prognostic information in coronary artery disease (CAD). Elevated levels of white blood cell subtypes may play different roles in atherothrombosis and predict cardiovascular outcomes. Methods and Results The association between white blood cell counts and mortality was evaluated in 823 subjects with angiographically demonstrated and clinically stable CAD in an observational-longitudinal study.

Serum Uric Acid Levels, but Not rs7442295 Polymorphism of SCL2A9 Gene, Predict Mortality in Clinically Stable Coronary Artery Disease.

Serum uric acid (SUA) has been associated with cardiovascular disease, but up to now whether SUA is an independent cardiovascular risk factor or merely a disease-related epiphenomenon remains still controversial. within the framework of the Verona Heart Study, we prospectively followed 703 subjects with angiographically demonstrated and clinically stable coronary artery disease between May 1996 and March 2007. At baseline, SUA levels were measured in all the patients.

Deep vein thrombosis in SARS-CoV-2 pneumonia-affected patients within standard care units: Exploring a submerged portion of the iceberg.

• An association between COVID-19 and venous thromboembolism (VTE) is now recognized. • The prevalence of VTE is high in COVID-19 patients hospitalized in standard care units. • The prevalence of VTE is high even though thromboprophylaxis and in patients estimated at low risk.

Development of Algorithm for Clinical Management of Sickle Cell Bone Disease: Evidence for a Role of Vertebral Fractures in Patient Follow-up.

Sickle-cell disease (SCD) is a worldwide distributed hemoglobinopathy, characterized by hemolytic anemia associated with vaso-occlusive events. These result in acute and chronic multiorgan damage. Bone is early involved, leading to long-term disability, chronic pain and fractures.

Aptamer-modified FXa generation assays to investigate hypercoagulability in plasma from patients with ischemic heart disease.

Background: High plasma levels of activated Factor VII-Antithrombin complex (FVIIa-AT) have been associated with an increased risk of cardiovascular mortality in patients with stable coronary artery disease (CAD).

Objectives: To investigate if FVIIa-AT levels are associated with activated factor X generation (FXaG) in modified assays.

Patients/methods: Forty CAD patients were characterized for FVIIa-AT levels by ELISA and for FXaG in plasma.

Apolipoprotein C-III Strongly Correlates with Activated Factor VII-Anti-Thrombin Complex: An Additional Link between Plasma Lipids and Coagulation.

Activated factor VII-anti-thrombin (FVIIa-AT) complex is a potential biomarker of pro-thrombotic diathesis reflecting FVIIa-tissue factor (TF) interaction and has been associated with mortality in patients with coronary artery disease (CAD). Previous data indicated plasma lipids as predictors of FVIIa-AT variability, and plasma lipoproteins as potential stimulators of the coagulation cascade. Our aim was to evaluate the relationships between FVIIa-AT plasma concentration and a broad apolipoprotein profile (including ApoA-I, ApoB, ApoC-III and ApoE).

Increased plasma thrombin potential is associated with stable coronary artery disease: An angiographically-controlled study.

Introduction: Coagulation plays a crucial role in coronary artery disease (CAD) contributing to both atherosclerotic plaque development and acute thrombotic complications, like myocardial infarction (MI). Coagulation biomarkers have been linked with ischemic heart disease, but results are still controversial.

Materials And Methods: D-dimer and thrombin generation, two "overall" coagulation assays, were evaluated in 775 subjects with or without angiographically-proven CAD (170 CAD-free and 605 CAD, 355 of whom with history of previous MI).

Experimental and numeric stress analysis of titanium and zirconia one-piece dental implants.

Purpose: To compare the stress in bone around zirconia and titanium implants under loading.

Materials And Methods: A one-piece zirconia implant and a replica of the same implant made of commercially pure titanium were embedded in two self-curing acrylic resin blocks. To measure strain, a strain gauge was applied on the surface of the two samples.

Three-dimensional finite-element analysis of a central lower incisor under labial and lingual loads.

Introduction: The aim was to evaluate the differences between labial and lingual application of an orthodontic force. This was achieved using a three-dimensional CAD design software model of a real lower incisor surrounded by a prismatic representation of the mandibular bone. This model was subjected to various loading conditions, with finite-element analysis.

The effect of temperature on the mechanical behavior of nickel-titanium orthodontic initial archwires.

Objectives: To investigate and compare the characteristics of commonly used types of traditional and heat-activated initial archwires at different temperatures by plotting their load/deflection graphs and quantifying three parameters describing the discharge plateau phase.

Materials And Methods: Forty-eight archwires of cross-sectional diameters ranging from 0.010 inches to 0.

Load deflection characteristics and force level of nickel titanium initial archwires.

Objectives: To investigate and compare the characteristics of commonly used types of traditional and heat-activated initial archwire by plotting their load/deflection graphs and quantifying three suitable parameters describing the discharge plateau phase.

Materials And Methods: Forty-eight archwires (22 nickel titanium [NiTi] and 26 heat-activated) of cross-sectional diameter ranging from 0.010 to 0.

A numerical model for durotaxis.

Cell migration is a phenomenon that is involved in several physiological processes. In the absence of external guiding factors it shares analogies with Brownian motion. The presence of biochemical or biophysical cues, on the other hand, can influence cell migration transforming it in a biased random movement.

Optimal palatal configuration for miniscrew applications.

Objective: To test the hypothesis that palatal bone is not able to support titanium miniscrews (11 mm in length and 2 mm in diameter) when subjected to forces normally generated during orthodontic treatment.

Materials And Methods: The miniscrew-palatal bone system was modeled and analyzed using the commercial finite element method software ANSYS Multiphysics 10.0; tests were done in both a state of total osseointegration and in the absence of it.