The value of the current histological scores and classifications of ANCA glomerulonephritis in predicting long-term outcome.

Background: Three different histological scores-histopathologic classification (Berden), Renal Risk Score (RRS) and the Mayo Clinic Chronicity Score (MCCS)-for anti-neutrophil cytoplasmic antibody (ANCA)-associated glomerulonephritis (ANCA-GN) were compared to evaluate their association with patient and kidney prognosis of ANCA-GN.

Methods: Patients aged >18 years with at least 1 year of follow-up and biopsy-proven ANCA-GN entered this retrospective study. Renal biopsies were classified according to Berden's classification, RRS and MCCS.

Corrigendum to "Changing Phenotypes and Clinical Outcomes Over Time in Microscopic Polyangiitis" [ Volume 8, Issue 10, October 2023, Pages 2107-2116].

[This corrects the article DOI: 10.1016/j.ekir.

Changing Phenotypes and Clinical Outcomes Over Time in Microscopic Polyangiitis.

Introduction: Diagnosis and management of microscopic polyangiitis (MPA) have evolved considerably over the past decades, but it is unknown whether clinical and histological presentation and patient and renal outcomes have changed accordingly.

Methods: We compared clinical and histopathological characteristic at diagnosis, risk of death, end-stage kidney disease (ESKD), and relapse rate in patients diagnosed with MPA between 1980 and 2022, after grouping them in 2 periods (p): p1980-2001 and p2002-2022. We compared the mortality rate between the 2 periods using Kaplan-Meier estimator and Cox-regression, and competing risks of ESKD and death using the Aalen-Johansen estimator, Fine-Gray multiple regression, and multistate models.

The muon Smasher's guide.

We lay out a comprehensive physics case for a future high-energy muon collider, exploring a range of collision energies (from 1 to 100 TeV) and luminosities. We highlight the advantages of such a collider over proposed alternatives. We show how one can leverage both the point-like nature of the muons themselves as well as the cloud of electroweak radiation that surrounds the beam to blur the dichotomy between energy and precision in the search for new physics.

Light Dark Matter at Neutrino Experiments.

Sub-GeV dark matter particles up-scattered by cosmic rays gain enough kinetic energy to pass the thresholds of large volume detectors on Earth. We then use public Super-Kamiokande and MiniBooNE data to derive a novel limit on the scattering cross section of dark matter with electrons that extends down to sub-keV masses, closing a previously allowed wide region of parameter space. We finally discuss search strategies and prospects at existing and planned neutrino facilities.

R-Axion at Colliders.

We study the effective theory of a generic class of hidden sectors where supersymmetry is broken together with an approximate R-symmetry at low energy. The light spectrum contains the gravitino and the pseudo-Nambu-Goldstone boson of the R-symmetry, the R-axion. We derive new model-independent constraints on the R-axion decay constant for R-axion masses ranging from GeV to TeV, which are of relevance for hadron colliders, lepton colliders, and B factories.

In vitro inhibitory potential of Cynara scolymus, Silybum marianum, Taraxacum officinale, and Peumus boldus on key enzymes relevant to metabolic syndrome.

Boldocynara®, a proprietary dietary supplement product consisting of the plants Cynara scolymus, Silybum marianum, Taraxacum officinale, and Peumus boldus, used to promote functions of the liver and the gallbladder. It was the aim of the present study to look from a different perspective at the product by investigating the in vitro potential of Boldocynara® as a combination product and its individual extracts on key enzymes relevant to metabolic syndrome. Peumus boldus extract exhibited pronounced inhibitory activities on α-glucosidase (80% inhibition at 100 µg/ml, IC50: 17.