Publications by authors named "Filippo S"
Article Synopsis
- Trauma, particularly traumatic brain injury (TBI), is a significant cause of maternal mortality during pregnancy, yet there is a lack of guidelines for managing these cases.
- An international survey with 122 physicians from 110 centers revealed that many do not have specific protocols for TBI in pregnant patients and highlighted a preference for using MRI and varying practices regarding transfusions and treatment methods.
- The findings indicate substantial inconsistency in how severe TBI is managed in pregnant individuals, suggesting a need for more research and education to standardize care.
Article Synopsis
- Pediatric patients with congenital heart disease (CHD) often receive low dose ionizing radiation during cardiac catheterizations (CC) for diagnosis and treatment, but the long-term cancer risks associated with this radiation are not well understood.
- A study was conducted with a French cohort of over 17,000 children who had their first CC between 2000 and 2013, tracking them for factors leading to lympho-hematopoietic malignancies.
- The results showed no increased risk of these cancers related to the low dose radiation from CC, however, more extensive studies are suggested for better understanding the relationship between radiation exposure and cancer risk.
Background: Ventricular arrhythmias and sudden death are recognized complications in tetralogy of Fallot. Electrophysiological studies (EPS) before pulmonary valve replacement (PVR), the most common reintervention in tetralogy of Fallot, could potentially inform therapy to improve arrhythmic outcomes.
Methods: A prospective multicenter study was conducted to systematically assess EPS with programmed ventricular stimulation in patients with tetralogy of Fallot referred for PVR from January 2020 to December 2021.
Moderate and severe traumatic brain injury (TBI) are major causes of disability and death. In addition, when TBI occurs during pregnancy, it can lead to miscarriage, premature birth, and maternal/fetal death, engendering clinical and ethical issues. Several recommendations have been proposed for the management of TBI patients; however, none of these have been specifically applied to pregnant women, which often have been excluded from major trials.
View Article and Find Full Text PDFObjectives: This study aimed to assess the incidence, associated factors, and outcomes of atrial arrhythmias in adults with atrioventricular septal defect (AVSD).
Background: Data regarding atrial arrhythmias in adults with AVSD are particularly scarce.
Methods: Data were analyzed from a multicentric cohort of adult patients with AVSD.
The vertebrate left-right axis is specified during embryogenesis by a transient organ: the left-right organizer (LRO). Species including fish, amphibians, rodents and humans deploy motile cilia in the LRO to break bilateral symmetry, while reptiles, birds, even-toed mammals and cetaceans are believed to have LROs without motile cilia. We searched for genes whose loss during vertebrate evolution follows this pattern and identified five genes encoding extracellular proteins, including a putative protease with hitherto unknown functions that we named ciliated left-right organizer metallopeptide (CIROP).
View Article and Find Full Text PDFBackground: Although patients with systemic right ventricle (SRV) represent a significant proportion of patients with congenital heart disease (CHD) implanted with cardiac resynchronization therapy (CRT), there are limited and conflicting data in this specific patient group.
Objective: We aimed to analyze outcomes of patients with SRV implanted with a CRT device.
Methods: Data were analyzed from an observational, retrospective, multicenter cohort study including all patients with CHD implanted with a CRT device from 6 French centers from 2004 to 2020.
Could Kallikrein-Related Serine Peptidase 3 Be an Early Biomarker of Environmental Exposure in Young Women?
Int J Environ Res Public Health
August 2021
Article Synopsis
- Bisphenols and phthalates impact androgen receptor signaling, which influences KLK3 secretion, suggesting environmental factors may affect this process.
- A study measured serum KLK3 levels in healthy women from high and low environmental impact areas, finding higher levels in the high impact group, especially during ovulation.
- Significant differences in KLK3 levels corresponded with lower progesterone levels in the high impact group during the luteal phase, indicating a potential link between environmental pollution and female reproductive health.
Purpose: The COCCINELLE study is a nationwide retrospective French cohort set up to evaluate the risk of cancer in patients who undergone cardiac catheterisation (CC) procedures for diagnosis or treatment of congenital heart disease during childhood.
Participants: Children who undergone CC procedures from 1 January 2000 to 31 December 2013, before the age of 16 in one of the 15 paediatric cardiology departments which perform paediatric CC in mainland France were included. The follow-up started at the date of the first recorded CC procedure until the exit date, that is, the date of death, the date of first cancer diagnosis, the date of the 18th birthday or the 31 December 2015, whichever occurred first.
Article Synopsis
- Advances in pediatric cardiology have enhanced survival rates for children with inherited cardiac disorders, but there's limited research on how these conditions affect their quality of life (QoL) and physical activity.
- The QUALIMYORYTHM trial is a multicenter study aimed at comparing the QoL of children aged 6 to 17 with inherited cardiac arrhythmias or cardiomyopathies to that of healthy peers and examining various factors influencing their QoL.
- Results from this trial seek to provide stronger evidence for guidelines regarding sports participation for young athletes with inherited cardiac disorders, moving beyond reliance on expert opinions.
Article Synopsis
- - The study focuses on the management of anomalous aortic origin of a coronary artery, which can be linked to sudden death in young individuals, especially those with an inter-arterial course.
- - Over a 25-year period, 100 patients were diagnosed, with higher rates of syncope and sudden death among those with an inter-arterial course compared to others (23.4% vs 0%).
- - Surgical repair was performed on 61 patients, all of whom had the inter-arterial course and were asymptomatic after an average follow-up of about 5 years, suggesting that surgical intervention is a viable option even for asymptomatic cases.
Article Synopsis
- The study evaluated the effect of pulmonary valve replacement (PVR) on the incidence of ventricular arrhythmias in tetralogy of Fallot (TOF) patients who have implantable cardioverter-defibrillators (ICDs).
- Results showed that among the 165 TOF patients monitored, those who underwent PVR experienced significantly fewer appropriate ICD therapies after the surgery compared to before, indicating a reduction in arrhythmia burden.
- The findings suggest that PVR may play a crucial role in decreasing the risk of arrhythmias and highlight the importance of considering PVR in the treatment plans for high-risk TOF patients.
Background: The aim of the study was to document cardiovascular clinical findings, cardiac imaging, and laboratory markers in children presenting with the novel multisystem inflammatory syndrome associated with coronavirus disease 2019 (COVID-19) infection.
Methods: This real-time internet-based survey has been endorsed by the Association for European Paediatric and Congenital Cardiologists Working Groups for Cardiac Imaging and Cardiovascular Intensive Care. Children 0 to 18 years of age admitted to a hospital between February 1 and June 6, 2020, with a diagnosis of an inflammatory syndrome and acute cardiovascular complications were included.
Article Synopsis
- A study screened 80 fetuses with congenital heart defects (CHDs) or heterotaxy, revealing a 12.5% pathogenic variant rate, especially higher in those with heterotaxy.
- Most fetuses were male, and a significant portion had additional anomalies beyond heart defects.
- The study found that genetic counseling for future pregnancies is more effective with these results, highlighting unexpected consanguinity in 20% of cases with identified variants.
Article Synopsis
- Advances in managing complex congenital heart disease have improved survival rates for adults with Fontan-like circulation, but their health status and quality of life remain concerns.* -
- A study involving 60 patients assessed through the SF-36 questionnaire revealed that while their physical health scores were lower than the general population, many reported good quality of life, linked to factors like education and occupation.* -
- Overall, the findings indicate that although adult Fontan patients experience poor physical health, they maintain a favorable perception of their quality of life, suggesting that supportive factors outside of cardiac health play a critical role.*
Background: Abnormal coronary pattern may complicate coronary transfer during arterial switch operation.
Objective: To evaluate the accuracy of echocardiography in assessing the anatomy of coronary arteries in neonates with transposition of the great arteries, and determine impact on outcomes.
Methods: We conducted a retrospective analysis of data in neonates with transposition of the great arteries.
Context: In the last 10 years, assisted reproductive technologies (ARTs) have offered infertile couples an opportunity to complete their reproductive project. However, the high failure rate could be explained with the complex human reproduction system. In ART, the decrease of the success is due to the conditions far from the natural ones.
View Article and Find Full Text PDFBackground: Our purpose was to determine the complication rate from intravascular ultrasound (IVUS) in a large, multicenter cohort of pediatric heart transplant (PHT) patients.
Methods: We retrospectively reviewed all PHT who underwent IVUS at 5 institutions (2006-2014). Rates of major and minor complications were calculated.
Clinical outcomes for congenital heart disease patients presenting with infective endocarditis.
Expert Rev Cardiovasc Ther
June 2020
Introduction: Infective endocarditis (IE) is a life-threatening adverse event for patients with congenital heart disease (CHD). Its incidence has changed little over time despite progress in techniques for diagnosis and treatment, and guidelines for prophylaxis.
Areas Covered: The review sought for key-words: 'congenital heart disease,' 'infective endocarditis,' 'microbial diagnosis,' 'imaging diagnosis,' 'surgical techniques,' 'prognosis,' 'prophylaxis.
The population of patients with congenital heart disease (CHD) is continuously increasing, and a significant proportion of these patients will experience arrhythmias because of the underlying congenital heart defect itself or as a consequence of interventional or surgical treatment. Arrhythmias are a leading cause of mortality, morbidity and impaired quality of life in adults with CHD. Arrhythmias may also occur in children with or without CHD.
View Article and Find Full Text PDFArticle Synopsis
- Some kids with COVID-19 can get really sick and have heart problems, even if it's usually mild in children.
- A study looked at 35 kids who had serious heart issues and high inflammation during the pandemic.
- Luckily, most of the kids got better, and no one died, showing that doctors can help them recover from these heart problems.
: The objective of this study is to evaluate the application of National guidelines for prevention and clinical management of traumatic dental injuries (NGPCMTDI) in developmental age published by the Italian Ministry of Health. : In the present retrospective and multicenter study, 246 patients who underwent dental injury were selected to assess the management of the traumatic event compiled with the protocol provided by the National guidelines. Each health worker involved completed a form related to the dental injury in order to standardize the collected data.
View Article and Find Full Text PDFAbout 10-20% of patients with Kawasaki disease (KD) are unresponsive to intravenous immunoglobulin (IVIg) and are at increased risk of coronary artery abnormalities (CAAs). Early identification is critical to initiate aggressive therapies, but available scoring systems lack sensitivity in non-Japanese populations. We investigated the accuracy of 3 Japanese scoring systems and studied factors associated with IVIg unresponsiveness in a large multiethnic French population of children with KD to build a new scoring system.
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