Publications by authors named "Filippo Martelli"
Article Synopsis
- Identical translocations involving the TFE3 gene have been linked to various tumors, including specific renal and soft tissue cancers like alveolar soft part sarcoma and clear cell stromal tumor of the lung.
- This review focuses on the clinicopathologic and molecular characteristics of TFE3-rearranged renal tumors, highlighting the complexity in their classification due to differing tumor types and features.
- While the reason for the diverse morphologies associated with similar gene fusions remains unclear, the pathology community still supports maintaining distinct classifications for TFE3-rearranged renal cell carcinoma and TFE3-rearranged PEComa.
Article Synopsis
- Fumarate hydratase (FH)-deficient renal cell carcinomas are uncommon but aggressive tumors linked to mutations in the FH gene, displaying significant morphological variability and often spreading rapidly to distant organs.
- In a study of 11 primary tumors and 7 metastases, most metastases were found in abdominal lymph nodes and the peritoneum, with tissue examination revealing diverse structures that can differ from the original tumors.
- The research highlighted that while 60% of primary tumors showed PD-L1 expression, there were no identified EGFR mutations, suggesting the potential for targeted immunotherapy and the importance of accurate diagnosis to differentiate these tumors from other conditions.
Pancreatic cancer, most frequently as ductal adenocarcinoma (PDAC), is the third leading cause of cancer death. Clear-cell primary adenocarcinoma of the pancreas (CCCP) is a rare, aggressive, still poorly characterized subtype of PDAC. We report here a case of a 65-year-old male presenting with pancreatic neoplasia.
View Article and Find Full Text PDFObjectives: The high incidence of prostate cancer causes prostatic samples to significantly affect pathology laboratories workflow and turnaround times (TATs). Whole-slide imaging (WSI) and artificial intelligence (AI) have both gained approval for primary diagnosis in prostate pathology, providing physicians with novel tools for their daily routine.
Methods: A systematic review according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines was carried out in electronic databases to gather the available evidence on the application of AI-based algorithms to prostate cancer.
The tumor showed extensive microcalcifications and cells with oval, nuclei and a clear perinuclear halo (A), positive immunostaining for OLIG-2 (B), GFAP (C), and CD34 (D), and intermingled Neu-N-positive neurons (E). FISH revealed multiple signals for the centromere of chromosome 7 (gains) (green probe) and the EGFR locus (red probe) (F, left), and a single signal for the centromere of chromosome 10 (loss) (F, right).
View Article and Find Full Text PDFSignet-ring cell (SRC)/poorly cohesive cell carcinoma is an aggressive variant of pancreatic ductal adenocarcinoma (PDAC). This study aimed to clarify its clinicopathologic and molecular profiles based on a multi-institutional cohort of 20 cases. The molecular profiles were investigated using DNA and RNA sequencing.
View Article and Find Full Text PDFArticle Synopsis
- Intraductal oncocytic papillary neoplasm (IOPN) is a unique type of pancreatic lesion and a precursor to pancreatic cancer, distinguished from intraductal papillary mucinous neoplasms (IPMNs).
- This study used immunohistochemistry and artificial intelligence to analyze the immune environment in IOPNs, finding that CD8+ T lymphocytes were the most prevalent immune cells, and all tumors showed an activated PD-1/PD-L1 axis.
- The research indicated that while invasive IOPNs had fewer CD4+ cells and larger regions of CD8+ cells, the presence of these immune cells might contribute to the better survival rates observed in IOPN patients.
Pancreatic ductal adenocarcinoma (PDAC) and distal cholangiocarcinoma (dCCA) are very aggressive tumors with a high mortality rate. Pancreas and distal bile ducts share a common embryonic development. Hence, PDAC and dCCA exhibit similar histological features that make a differential diagnosis during routine diagnostic practice challenging.
View Article and Find Full Text PDFPancreatic neuroendocrine neoplasms (PanNENs) are rare neoplasms arising from islets of the Langerhans in the pancreas. They can be divided into two groups, based on peptide hormone secretion, functioning and nonfunctioning PanNENs. The first group is characterized by different secreted peptides causing specific syndromes and is further classified into subgroups: insulinoma, gastrinoma, glucagonoma, somatostatinoma, VIPoma and tumors producing serotonin and adrenocorticotrophic hormone.
View Article and Find Full Text PDFThe Virgo interferometer, aimed at detecting gravitational waves, is now in a commissioning phase. Measurements of its optical properties are needed for the understanding of the instrument. We present the techniques developed for the measurement of the optical parameters of Virgo.
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