Publications by authors named "Filippo Finizio"
Article Synopsis
- Tethering is a common issue in mitral valve problems, often seen in patients with serious regurgitation, but its true effects on treatment outcomes are not well understood.
- A study involving over 2,200 patients found that while those with tethering had higher initial rates of cardiac death and rehospitalization, after adjusting for other factors, tethering did not significantly impact long-term outcomes.
- Consequently, the study suggests that having tethering should not prevent suitable patients from undergoing transcatheter edge-to-edge repair (TEER) for mitral valve issues.
Article Synopsis
- Transcatheter mitral edge-to-edge repair (TEER) is a minimally invasive option for treating severe mitral regurgitation in patients with high surgical risk, but there are concerns regarding the risk of cerebrovascular accidents (CVAs) after the procedure.
- In a study of 2,238 patients, the incidence of CVAs was found to be low at 1.47%, with the majority occurring after hospital discharge and linked to preexisting conditions like atrial fibrillation and renal dysfunction.
- While CVAs did not significantly increase the risk of long-term or cardiac death, the study suggests the need for proactive antithrombotic therapy for patients at higher risk before and after TEER.
Article Synopsis
- Minimally invasive mitral valve repair using the MitraClip device shows beneficial outcomes in patients with significant mitral regurgitation, including those who have had prior valve repairs.
- A study involving 2,238 patients highlighted that while device and procedural success rates are slightly lower for those with previous valve procedures, overall outcomes such as death and rehospitalization rates remain similar across groups.
- The findings suggest that transcatheter edge-to-edge repair is a viable option for carefully selected patients even after previous mitral valve interventions.
Article Synopsis
- Transcatheter edge-to-edge repair (TEER) is an effective, minimally invasive method for treating significant mitral regurgitation and has seen advancements in device technology, specifically the NT, NTr, and XTr MitraClip devices.
- A study analyzed data from a large patient registry to compare these devices, focusing on patient outcomes after the procedure, specifically looking at complications and hospital discharge.
- Results showed that while the NT group faced worse outcomes initially, adjusted analyses indicated no significant differences in long-term results among the devices, suggesting that newer MitraClip devices provide better outcomes even when used on patients with more complex cases.
Background Little is known about the impact of transcatheter mitral valve edge-to-edge repair on changes in left ventricular ejection fraction (LVEF) and the effect of an acute reduction in LVEF on prognosis. We aimed to assess changes in LVEF after transcatheter mitral valve edge-to-edge repair for both primary and secondary mitral regurgitation (PMR and SMR, respectively), identify rates and predictors of LVEF reduction, and estimate its impact on prognosis. Methods and Results In this international multicenter registry, patients with both PMR and SMR undergoing transcatheter mitral valve edge-to-edge repair were included.
View Article and Find Full Text PDFBackground: The clinical impact of coronary artery disease (CAD) on the prognosis of patients undergoing MitraClip implantation is still unclear.
Methods: One thousand nine hundred fifty-three patients undergoing MitraClip implantation included in the multicenter GIOTTO Registry were stratified according to CAD. Endpoints were all-cause death, cardiac death, and re-hospitalization for heart failure at follow-up (median 15.
Article Synopsis
- The study analyzed the outcomes of patients receiving MitraClip treatment for mitral valve regurgitation, comparing those under 80 years old to octogenarians (80+ years).
- A total of 1853 patients were included, with similar in-hospital mortality rates and improvements in mitral regurgitation among both age groups.
- At a 15-month follow-up, while octogenarians had lower rates of rehospitalization and cardiac complications, once adjusting for various baseline characteristics, there were no significant differences in major outcomes between the age groups, indicating the procedure is safe for older patients.
Article Synopsis
- Transcatheter mitral valve repair (TMVR) using MitraClip™ is an effective treatment for mitral regurgitation (MR), with options for implanting one or multiple clips based on the severity of the condition.
- A study analyzed data from the GISE registry, comparing outcomes for patients with one, two, or multiple MitraClips, focusing on 1-year cardiac death or rehospitalization as the primary endpoint.
- The analysis included 1824 patients and revealed significant baseline health differences and procedural variations among those receiving different numbers of MitraClips, impacting clinical outcomes and recovery.
Introduction: Surgical coronary revascularization is being performed with ever increasing frequency in patients at high surgical risk. Off-pump coronary artery bypass grafting (OPCABG) is particularly appealing in such subjects, but may limit the options for concomitant mechanical circulatory support.
Presentation Of Case: We hereby report an original case of mechanical circulatory support with the Impella Recover LP 5.
We sought to determine QT variability pattern in patients with hypertrophic cardiomyopathy (HCM) and its relationship with the risk of syncope. QT interval variability was assessed from 24-hour Holter monitoring in 10 HCM patients with history of syncope, 10 HCM patients without history of syncope, and 10 healthy subjects. QT variability was higher in patients with HCM, in particular in those with history of syncope, than in healthy controls.
View Article and Find Full Text PDFBackground: We assessed the hemodynamic effects of isometric exercise by an ambulatory radionuclide monitoring device (VEST) that measured left ventricular function in patients who had hypertrophic cardiomyopathy (HCM), with and without significant left ventricular outflow-tract obstruction at rest, compared with control subjects.
Methods And Results: We studied 10 patients with obstructive HCM, 25 patients with nonobstructive HCM, and 11 control subjects. During VEST monitoring, all patients gripped a dynamometer at 75% of maximal strength for up to 5 minutes.
Objectives: We sought to assess the hemodynamics of exercise in patients with hypertrophic cardiomyopathy (HCM), with and without an exercise-induced abnormal blood pressure (BP) response, by ambulatory radionuclide monitoring of left ventricular (LV) function with the VEST device (Capintec Inc., Ramsey, New Jersey).
Background: Blood pressure fails to increase >20 mm Hg during exercise in about one-third of patients with HCM.