In the context of the Italian National Herpes Zoster Vaccine program, an exploratory survey was conducted on a sample of fragile adult patients to investigate the representations of the disease and its prevention to build future local vaccination campaigns. An ad hoc questionnaire was administered to 271 fragile adult patients who had adjuvanted recombinant Herpes Zoster vaccination to detect the following: knowledge and perception of the disease and its risks; information sources and confidence in the information sources used; and perception of the Herpes Zoster vaccination. Fragile adult patients have the representation of Herpes Zoster as a serious disease (86.
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