[APPLICATION OF PREPARATION OF COCARNIT FOR PATIENTS AFTER ENDOPROSTHESIS OF HIP AND KNEE JOINTS].

In the article the results of clinical researches of efficiency of preparation of Cocarnit are resulted for patients after endoprosthesis of large joints. It is routine that for patients, receiving preparation of Cocarnit after the operation period there was a decline in the amount of complaints of patients on the total somatical state. Preparation of Ccocarnit was positively estimated outside patients, meaningful by-reactions, serving reason of abolition of preparation, was not marked.

Serogroup quantitation of multivalent polysaccharide and polysaccharide-conjugate meningococcal vaccines from China.

The active components of most meningococcal vaccines are four antigenic serogroup capsular polysaccharides (A, C, Y, W135). The vaccines, monovalent or multivalent mixtures of either free polysaccharides or polysaccharides conjugated to antigenic carrier proteins, may be in liquid or lyophilised formulations, with or without excipients. Acid hydrolysis and chromatographic methods for serogroup quantitation, which were previously optimised and qualified using polysaccharide-based standards and a narrow range of real vaccines, are here challenged with multiple lots of a broad assortment of additional multivalent polysaccharide-based meningococcal vaccine products.

Oxidation of copper nanoparticles in water: mechanistic insights revealed by oxygen uptake and spectroscopic methods.

Oxidation of aqueous ∼8 nm unprotected copper nanoparticles takes place under air in approximately 2 hours at 30 °C to give Cu(2+) as a final product through an intermediate Cu(+) species. At 5 °C the process is about 5 times slower; similarly, vitamin C, which plays a sacrificial role, also slows down the oxidation, while CuNP catalyses the oxidation. In this work, we present a detailed analysis of the oxidation mechanism of colloidal CuNP inferred through spectroscopic methods (UV-visible and EPR) combined with oxygen uptake measurements, with emphasis on factors affecting the oxidative process.

Solvent-independent antioxidant activity from thermally generated carbon-centered radical antioxidants.

A new and unusual class of chain-breaking antioxidants has been discovered, where the actual antioxidant is, paradoxically, a carbon-centered radical. Properties of these molecules are currently being studied. The solvent dependence on antioxidant activity of the HP-136 dimer has been measured, in solvents of varying H-bond accepting ability, by the inhibited oxygen uptake (IOU) method.

Effect of UVC-induced damage to DNA on the intercalation of thiazole orange: a convenient reporter for DNA damage.

We report a novel method of identifying damage to DNA leading to the loss of intercalation sites. Thiazole orange (TO), an intercalating cyanine dye, fluoresces strongly when intercalated in DNA, but not free in solution. Upon UVC-induced damage to DNA, the change in TO fluorescence is greater than the change in any of the other spectral or biochemical indicators (absorbance, circular dichroism and agarose gel electrophoresis), thus providing a fast screening method to identify damage to DNA.

Nonstoichiometric hydroxyapatite granules for orthopaedic applications.

A new method for the preparation of nonstoichiometric hydroxyapatite (HA) "dense" and porous granules, round in form and up to 8 mm in sizes designed for application in orthopaedic surgery has been developed. The "dense" granules' porosity was up to 32% and they only contained micropores. They differed from that kind of granules by increased values of compression strength (up to 48 MPa).

[Plastic repair of the anterior wall of the maxillary sinus after sinusotomy with a complex autograft].

A method of repair of the maxillary sinus anterior wall after radical sinusotomy is presented. The defect is replaced by an osseomucosal autotransplant of an elongated shape cut out of the anterior sinus wall. After sinus revision the complex graft is placed transversely so that its edges overlap sinusal bone wound and fixed with sutures.

[Damage to the floor of the maxillary sinus and the therapeutic approach].

In 1974-1991 the authors followed up 402 and 220 patients with odontogenic and rhinogenic maxillary sinusitis, respectively. It is confirmed that the leading cause of odontogenic sinusitis is periapical inflammation, while perforation of the sinus base in removal of the tooth is the sequela. In dissection of the sinus base free of sinusitis suturing of the hole or its closure with mucoperiosteal graft may warrant the clot persistence in the hole.

[The potentials and outlook for the surgical treatment of complicated injuries and tumors of the spine by total vertebrectomy].

The use of vertebrectomy in 9 patients with long-standing complicated dislocation fractures of vertebrae and defects of tissues of the spinal cord from 1 up to 12 cm has shown that the operation of removal of up to 3 vertebrae is technically quite realizable. Clinical results however are yet minimum, which requires further search for methods of stimulation of regenerative processes in the zone of connection of the spinal cord stumps. The use of the method for treatment of 4 patients with tumors of the vertebrae has revealed a number of problems requiring a somewhat different approach both to the performance of the operation and to the following fixation of the backbone.

[The possibilities and outlook for the surgical treatment of complicated injuries and tumors of the spine by total vertebrectomy].

On the basis of experimental and clinical investigations the authors consider the removal of the vertebra body as the whole block to be the optimal variant. Shortening of the vertebral column is permissible for the approximation of ends of the spinal cord or its roots for suturing without intention. The use of vertebrectomy in 9 patients with long-standing dislocation fractures and defects of the spinal cord tissues from 1 to 12 cm and in 4 patient without tumors of the vertebrae has shown that the operation with removal of as many as 3 vertebrae is quite realizable technically.

[Single-stage total removal of the cervical vertebrae in plasmacytoma].

The article includes the description of successful case of surgical treatment of a patient (53 years old) with VC plasmocytoma, complicated with upper paraparesis, tetanoid paraplegia and pelvic disturbances. The patient has been subjected to complete removal of VC in one stage of 2 accesses. The patient's spine has been fixed by means of implant, made of corundum porous ceramic, metal plate and lavsan band.

[The uranoplasty of wide clefts in children].

Sixty children with wide palate clefts (open uni- and bilateral, and complete isolated), aged 2.5-13 years were operated on according to a new uranoplasty technique. The wounds healed by primary tension in 53 children; anatomical shape of the palate was completely restored, the palate elongated, and the pharyngeal ring narrowed.

[Changes in the spinal cord and the characteristics of the regenerative processes in experimental shortening of the spine].

In the experiment with 22 dogs the authors have studied the effect of the spine shortening on the undamaged and damaged spinal cord. Observation period ranged from 1 week to 6 months. Partial resection of the vertebral body without spine shortening, practically, have not affected the spinal cord of an animal.

[Intratumoral and parametric administration of metronidazole in the radiotherapy of cancer of the cervix].

The paper is concerned with analysis of the results of radiation therapy of cervical cancer and intratumoral administration of metronidazole (124 patients with tumors, Stage IIB and III). At the end of the treatment, complete tumor regression in the intervention group (with metronidazole) was noted in 91% (irrespective of a stage of disease), in the control group (without metronidazole)--in 51% of the patients.