Publications by authors named "Filippa L Qvist"
Article Synopsis
- Impaired sleep is common with aging and is linked to the onset of Alzheimer's disease; researchers studied the effects of sleep deprivation on both healthy mice and a mouse model of Alzheimer's.
- After sleep deprivation, both groups showed increased EEG slow-wave activity, but only healthy mice exhibited enhanced norepinephrine oscillations typical of good sleep.
- The Alzheimer’s model mice didn't show this enhancement 24 hours post-deprivation, along with a buildup of amyloid-β protein, suggesting that their disrupted sleep patterns may increase the risk of developing Alzheimer's.
The neurometabolic disorder succinic semialdehyde dehydrogenase (SSADH) deficiency leads to great neurochemical imbalances and severe neurological manifestations. The cause of the disease is loss of function of the enzyme SSADH, leading to impaired metabolism of the principal inhibitory neurotransmitter GABA. Despite the known identity of the enzymatic deficit, the underlying pathology of SSADH deficiency remains unclear.
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