Publications by authors named "Filipe Piastrelli"
16S rRNA amplicon sequencing and antimicrobial resistance profile of intensive care units environment in 41 Brazilian hospitals.
Front Public Health
July 2024
Introduction: Infections acquired during healthcare setting stay pose significant public health threats. These infections are known as Healthcare-Associated Infections (HAI), mostly caused by pathogenic bacteria, which exhibit a wide range of antimicrobial resistance. Currently, there is no knowledge about the global cleaning process of hospitals and the bacterial diversity found in ICUs of Brazilian hospitals contributing to HAI.
View Article and Find Full Text PDFApplication of ventilator-associated events (VAE) in ventilator-associated pneumonia (VAP) notified in Brazil (IMPACTO MR-PAV): a protocol for a cohort study.
BMJ Open
December 2023
Article Synopsis
- The IMPACTO MR-PAV study aims to compare the incidence and diagnostic accuracy of ventilator-associated pneumonia (VAP) in Brazil using local criteria versus those set by the US CDC, which could affect how events are detected and resources used in intensive care units.
- Conducted across 15 centers in Brazil from October 2022 to December 2023, trained professionals will gather data on VAP incidence and the effectiveness of both sets of surveillance criteria.
- The study is ethically approved and will inform better VAP surveillance methods in Brazil, with potential benefits for countries with similar diagnostic guidelines.
Objective: To describe the IMPACTO-MR, a Brazilian nationwide intensive care unit platform study focused on the impact of health care-associated infections due to multidrug-resistant bacteria.
Methods: We described the IMPACTO-MR platform, its development, criteria for intensive care unit selection, characterization of core data collection, objectives, and future research projects to be held within the platform.
Results: The core data were collected using the Epimed Monitor System® and consisted of demographic data, comorbidity data, functional status, clinical scores, admission diagnosis and secondary diagnoses, laboratory, clinical, and microbiological data, and organ support during intensive care unit stay, among others.
Objective: The coronavirus disease 2019 (COVID-19) pandemic has caused a global health crisis and may have affected healthcare-associated infection (HAI) prevention strategies. We evaluated the impact of the COVID-19 pandemic on HAI incidence in Brazilian intensive care units (ICUs).
Methods: In this ecological study, we compared adult patients admitted to the ICU from April through June 2020 (pandemic period) with the same period in 2019 (prepandemic period) in 21 Brazilian hospitals.
Article Synopsis
- - Clostridioides difficile (CD) is the leading cause of diarrhea in healthcare settings, and its severity has grown due to more aggressive strains.
- - The primary factor for CD's virulence is toxin production, but the study found other important genetic factors contributing to its virulence.
- - Researchers sequenced 38 strains and found most were toxigenic, with some lacking genes related to adhesion, highlighting the need to explore other virulence factors for a better understanding of CD.
Little is known about the role of lineage of strains of Clostridioides difficile (CD) on the clinical presentation of CD infection (CDI) in Latin America, especially regarding the treatment response. We conducted a multicenter, prospective study to investigate the predictive factors and treatment outcomes of CDI in hospitalized patients and to performed phenotypical and molecular characterization of CD strains. A total of 361 diarrheic patients at 5 hospitals from different regions of the country were enrolled.
View Article and Find Full Text PDFEpidemiological data on CD infection (CDI) in Latin American are scarce. CDI prevalence and strains characterization were prospectively evaluated in 5 Brazilian hospitals from different regions. Prevalence rates of CDI were 15%, ranging from 0 to 37%.
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