Publications by authors named "Filipe Calheiros Lourenco"
Anaplastic lymphoma kinase (ALK) is a receptor tyrosine kinase, initially discovered as part of the NPM-ALK fusion protein, resulting from the t(2;5) translocation that is frequently associated with anaplastic large-cell lymphomas. The native ALK protein is normally expressed in the developing and, at a weaker level, adult nervous system. We recently demonstrated that the oncogenic, constitutively kinase-activated NPM-ALK protein was antiapoptotic when expressed in Jurkat lymphoblastic cells treated with cytotoxic drugs.
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- UNC5H receptors, like UNC5H2, were thought to help nerves move in the right direction but are also involved in making cells self-destruct when not activated.
- UNC5H2 interacts with a protein called DAP-kinase, which plays a role in cell death, both in lab cells and in developing mouse brains.
- This interaction means that without a signal called netrin-1, UNC5H2 can increase DAP-kinase activity, potentially controlling when cells live or die.
The MET tyrosine kinase, the receptor of hepatocyte growth factor-scatter factor (HGF/SF), is known to be essential for normal development and cell survival. We report that stress stimuli induce the caspase-mediated cleavage of MET in physiological cellular targets, such as epithelial cells, embryonic hepatocytes, and cortical neurons. Cleavage occurs at aspartic residue 1000 within the SVD site of the juxtamembrane region, independently of the crucial docking tyrosine residues Y1001 or Y1347 and Y1354.
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