Publications by authors named "Filipa Capelinha"
Article Synopsis
- Breast cancer (BC) is a major health issue for women worldwide, and there's a growing need for innovative methods to help clinicians monitor and treat it more effectively through metabolomic studies.
- The research employed nuclear magnetic resonance (NMR) and gas chromatography-quadrupole mass spectrometry (GC-qMS) to analyze urine and breast tissue samples from both BC patients and cancer-free individuals, aiming to identify distinct metabolite patterns.
- Results showed strong discrimination between the two groups based on metabolomic data, with high predictive accuracy, and uncovered several disrupted metabolic pathways in BC, indicating areas for further research and potential treatment targets.*
Purpose: One of the hallmarks of cancer cells is the demand of supply for the synthesis of new membranes involved in cell proliferation and lipids have an important role in cellular structure, signaling pathways and progression of cancer. In this sense, lipid studies have become an essential tool allowing the establishment of signatures associated with breast cancer (BC). In this regard, some metabolic processes including proteins, nucleic acids and lipid synthesis are enhanced as part of cancer-associated metabolic reprogramming, as a requirement for cell growth and proliferation.
View Article and Find Full Text PDFBreast cancer (BC), ranked as the fifth amongst all cancers, remains at the top of women's cancers worldwide followed by colorectal, lung, cervix, and stomach cancers. The main handicap of most of the screening/diagnostic methods is based on their low sensitivity and specificity and the invasive behavior of most sampling procedures. The aim of this study was to establish the volatomic pattern of BC and cancer-free (CF) tissues (n = 30) from the same patients, as a powerful tool to identify a set of volatile organic metabolite (VOM) potential BC biomarkers which might be used together or complement with the traditional BC diagnostics strategies, through the integration of chromatographic data, obtained by solid-phase microextraction followed by gas chromatography-mass spectrometry (SPME/GC-qMS), with chemometric tools.
View Article and Find Full Text PDFContext: It is well recognized that celiac disease is an immune-mediated systemic disorder highly prevalent among relatives of celiac patients.
Objectives: The aim of this study is to determine the prevalence of celiac disease in a group of first degree relatives of celiac children, and to access the frequency of human leukocyte antigen HLA-DQ2 and DQ8 in celiac disease patients and their affected relatives.
Methods: A survey was conducted of 39 children with celiac disease with follow-up in the Pediatric outpatient's clinic of Dr.