Publications by authors named "Filip Siljehult"
Objectives: The aim of this study was to validate the use of survivin for preclinical recognition of rheumatoid arthritis (RA) among patients with unexplained arthralgia.
Methods: Serum levels of survivin and the arthritis-specific autoantibodies RF and ACPA were measured in total of 5046 patients with musculoskeletal complains during 12 consecutive months in Gothenburg and in Umeå. Among them, 303 arthralgia patients were identified and prospectively followed.
Article Synopsis
- A EULAR-taskforce developed a definition for arthralgia that indicates a higher likelihood of evolving into rheumatoid arthritis (RA), aimed at creating consistent patient groups for clinical studies.
- This study validated the definition in 241 patients identified as having clinically suspect arthralgia (CSA) and assessed its performance in another group of 113 referred patients.
- Results indicated that the definition is effective when used by rheumatologists, but much less so without their evaluation, suggesting that clinical assessment should be paired with biomarkers for better diagnostic accuracy.