Publications by authors named "Filip Hanak"
Article Synopsis
- The renin-angiotensin system (RAS) plays a crucial role in various physiological processes and impacts multiple organs, with ACE being pivotal in managing pain-related peptides.
- ACE inhibitors (ACEis) are used to treat several disorders, but they may also cause side effects like increased pain sensitivity and mechanical allodynia.
- This review highlights the need for more research on ACE and its role in pain perception, given the complexity of RAS signaling and the effects of ACE substrates.
Article Synopsis
- The endogenous opioid system helps regulate pain through the release of neuropeptides, but opioid peptides like enkephalins are quickly broken down by enzymes, limiting their effectiveness.
- A novel approach to manage pain involves developing inhibitors that prevent the breakdown of enkephalins, with previous studies identifying a promising compound that needs refinement to avoid toxic side effects.
- The new compound improved pain relief and showed strong interaction with opioid receptors, while further research indicated it has good stability in the body and supports the continued development of these inhibitors for better pain management.
Article Synopsis
- The endogenous opioid system manages pain through neuropeptides like enkephalins, but their effectiveness is limited because they are quickly broken down by enzymes.
- An innovative solution proposed is to create drugs that inhibit these enzymes, specifically puromycin sensitive aminopeptidase (PSA), to increase the stability and concentration of enkephalins for longer-lasting pain relief.
- New derivatives of existing compounds showed promise by maintaining PSA inhibition without causing toxicity, leading to significant pain reduction in tests, and confirming the role of opioid receptors in the analgesic effects observed.
Purpose: The appropriate treatment of pulseless pink supracondylar humerus fractures (SCHF) remains controversial. In this study, the outcomes of two treatment approaches (with and without vascular surgery) were compared.
Material And Methods: This was a retrospective multicenter study of patients with pulseless pink SCHFs treated in ten pediatric surgery, trauma, or orthopedics departments in the Czech and Slovak Republic between 2014 and 2018.
The opioid epidemic has plagued the United States with high levels of abuse and poor quality of life for chronic pain patients requiring continuous use of opioids. New drug discovery efforts have been implemented to mitigate this epidemic; however, new medications are still limited by low efficacy and/or high side effect and abuse potential. Intermittent fasting (IF) has recently been shown to improve a variety of pathological states, including stroke and neuroinflammation.
View Article and Find Full Text PDFA new quasiclassical method for quantum autocorrelation functions based on the semiclassical limit in Wigner phase space has been derived. Unlike the existing quasiclassical method, the new method enables long-time simulations, thus making it possible to locate quantum spectral lines very precisely. The new method has been tested for a one-dimensional anharmonic oscillator fitted to the H(2) molecule and for a six-dimensional calculation of the Ar(2)I van der Waals cluster in adiabatic approximation.
View Article and Find Full Text PDF