[Bilateral uveitis associated with protein kinase inhibitor-based treatment of skin melanoma (case study)].

The article presents a clinical case of bilateral uveitis with macular edema that developed during long-term administration of vemurafenib. Methods of conservative treatment of malignant tumors are presently available and reasonably effective. However, at the same time drugs can have toxic effect on normal cells in various tissues of the body.

Long-term consequences of primary percutaneous coronary intervention in patients with st-elevation myocardial infarction.

Objective: The aim: To investigate long-term effects of primary percutaneous coronary interventions (pPCI) in patients with STEMI basing on the prevalence of clinically relevant endpoints.

Patients And Methods: Materials and methods: Totally 200 patients with STEMI hospitalized within a period of "therapeutic window" for revascularization were included into the study. 100 patients who additionally to pPCI underwent manual thromboaspiration entered the main group.

Ablation of atrial tachyarrhythmias late after surgical correction of tetralogy of Fallot: long-term follow-up.

Background: After the surgical correction of tetralogy of Fallot, surgical scars and natural obstacles form pathways capable of supporting an atrial tachyarrhythmia (AT). Radiofrequency (RF) ablation is effective, although the few studies published on this topic had relatively short follow-up periods.

Aim: The aims of the study were to evaluate the acute and long-term effects of RF ablation of AT and examine the charac-teristics of arrhythmia recurrence.

Validity and reliability of the International Cooperative Ataxia Rating Scale (ICARS) and the Scale for the Assessment and Rating of Ataxia (SARA) in multiple sclerosis patients with ataxia.

Background: Ataxia is an extremely common problem in multiple sclerosis (MS) patients. Thus, appropriate scales are required for detailed assessment of this issue. The aim of our study was to investigate the reliability and validity of the Turkish version of the International Cooperative Ataxia Rating Scale (ICARS) and Scale for the Assessment and Rating of Ataxia (SARA), which are widely used in ataxia evaluation in the context of other cerebellar diseases.

Effects of different exercise modalities on ataxia in multiple sclerosis patients: a randomized controlled study.

Purpose: To investigate the effects of different exercise protocols on ataxia in patients with multiple sclerosis (MS).

Method: A total of 42 MS patients, 17 male and 25 female (Expanded Disability Status Scale (EDSS): 3-5), were enrolled in this randomized controlled study. The patients were divided into three groups: a balance training (BT) group, a lumbar stabilization (LS) group and a task-oriented training (TT) group.

Resistive reduced MHD modeling of multi-edge-localized-mode cycles in Tokamak X-point plasmas.

The full dynamics of a multi-edge-localized-mode (ELM) cycle is modeled for the first time in realistic tokamak X-point geometry with the nonlinear reduced MHD code jorek. The diamagnetic rotation is found to be instrumental to stabilize the plasma after an ELM crash and to model the cyclic reconstruction and collapse of the plasma pressure profile. ELM relaxations are cyclically initiated each time the pedestal gradient crosses a triggering threshold.

Mechanism of edge localized mode mitigation by resonant magnetic perturbations.

A possible mechanism of edge localized modes (ELMs) mitigation by resonant magnetic perturbations (RMPs) is proposed based on the results of nonlinear resistive magnetohydrodynamic modeling using the jorek code, realistic JET-like plasma parameters and an RMP spectrum of JET error-field correction coils (EFCC) with a main toroidal number n=2 were used in the simulations. Without RMPs, a large ELM relaxation is obtained mainly due to the most unstable medium-n ballooning mode. The externally imposed RMP drives nonlinearly the modes coupled to n=2 RMP which produce small multimode relaxations, mitigated ELMs.

Pain in Parkinson disease: a review of the literature.

Parkinson's disease (PD) is a degenerative neurological disease presenting with motor and non-motor signs and symptoms. Approximately 30-50% of the patients experience pain. There is no consensus regarding the mechanisms and classification of pain in PD.

Thermal and mechanical pain thresholds in patients with fluctuating Parkinson's disease.

Study results evaluating pain thresholds in patients with Parkinson's disease (PD) vary widely. Thus, we designed our study to determine the effects of levodopa on the thresholds of pressure (PPT), heat (HPT) and cold pain (CPT) in PD patients with motor fluctuations (18 patients: 10 men, 8 women; age: 65 ± 10 years; mean disease duration: 11.6 ± 6 years), six of whom (33%) reported pain related to their disease.

The effect of electrical stimulation in combination with Bobath techniques in the prevention of shoulder subluxation in acute stroke patients.

Objective: To examine the efficiency of electrical stimulation in combination with Bobath techniques in the prevention of inferior and anterior shoulder subluxation in acute stroke patients.

Design: A prospective randomized controlled trial.

Setting: Intensive care unit and inpatient clinics of neurology in a university hospital.

Changes in gait velocity, mean knee flexion in stance, body mass index, and popliteal angle with age in ambulatory children with cerebral palsy.

Background: The purpose of this study was to explore changes in body mass index (BMI), gait velocity, mean knee flexion in stance, and popliteal angle with age in ambulatory children with cerebral palsy.

Methods: A cross-sectional sample of 188 ambulatory children with cerebral palsy Gross Motor Function Classification System II or III who had a motion analysis evaluation. Subjects had no previous surgical interventions and were between the ages of 4 and 21.