A new one-pot hydroformylation/Strecker synthesis as a versatile synthetic tool for polyfunctional compounds and functionalization of dendrimers.

A versatile and high yielding one-pot hydroformylation/Strecker synthesis is reported for the synthesis of various alpha-aminonitriles. This methodology allows functionalization of dendrimers (e.g.

Synthesis of polyamines via hydroaminomethylation of alkenes with urea--a new, effective and versatile route to dendrons and dendritic core molecules.

Polyamines, structurally related to putrescines and spermidines, are easily obtainable via hydroaminomethylation of methylallylphthalimide with primary or secondary amines. In addition, hydroaminomethylation of monoolefins with urea as a synthetic equivalent for ammonia, in contrast to other methods (e.g.

Highly regioselective synthesis of amino-functionalized dendritic polyglycerols by a one-pot hydroformylation/reductive amination sequence.

[reaction: see text] Dendritic architectures with neutral core structures and amines groups in the shell are a synthetic challenge, and there is a need for an efficient access. In this paper, highly selective Rh-catalysts are used for sequential hydroformylation/reductive amination of dendritic perallylated polyglycerols 1 with various amines in a one-pot procedure to give dendritic polyamines 3a-e in high yields (73-99%). In all cases, complete conversion of the allyl ether and aldehyde intermediate has been observed.