Publications by authors named "Fikile C Mabena"
Background: Viridans Group Streptococci (VGS) are often considered organisms of low virulence; however, infection can result in clinically significant sepsis and life-threatening complications in paediatric patients.
Objectives: This study aimed to describe the spectrum of clinical presentation of VGS bacteraemia in paediatric patients, to analyse risk factors, and to describe the antibiotics resistance patterns of VGS.
Method: Cultures of VGS in paediatric patients admitted to Chris Hani Baragwanath Academic Hospital in 2019 were identified through National Health Laboratory Service.
Background: Neonatal colonization with multidrug-resistant (MDR) Enterobacter spp., Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa and Enterococcus faecium (ESKAPE) and Candida spp. often precedes invasive hospital-acquired infections.
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- The study compares the histopathological and microbiological features of deceased patients with respiratory symptoms related to SARS-CoV-2 versus other causes at a South African hospital during the COVID-19 pandemic.
- Out of the deceased adult patients, 75 had COVID-19, and 42 had non-COVID-related causes, with lower HIV and MTB infections found in the COVID+ group.
- Key findings showed significant differences in lung histopathology, especially in Type-II pneumocytes' conditions, but no significant correlation was found between HIV or MTB infections and COVID-related deaths.
Background: Globally, very few childhood deaths have been attributed to coronavirus disease 2019 (COVID-19). We evaluated clinical, microbiologic and postmortem histopathologic findings in childhood deaths in whom severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was identified antemortem or postmortem.
Methods: Surveillance of childhood deaths was ongoing during the initial COVID-19 outbreak in South Africa from April 14, 2020, to August 31, 2020.