Publications by authors named "Figen Gulen"

Background: Since January 2015, the Cystic Fibrosis National Newborn Bloodspot Screening (CF-NBS) program has been implemented in Turkey with two samples of immune reactive trypsinogen (IRT-1/IRT-2) testing.

Aims: This study aimed to evaluate the Turkish national CF screening program, which included patients referred to a tertiary pediatric pulmonology center, to ascertain the optimal cut-off values for IRT-1/IRT-2 and to identify alternative strategies for mitigating the number of late-diagnosed false-negative patients (FNPs) who initially exhibited screen negative results but were diagnosed subsequently based on clinical suspicion. The study also compared NBS-positive patients to FNPs to determine the influence of delayed diagnosis.

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  • This study analyzed the differences in clinical presentations and severity of influenza A (FLUA) and influenza B (FLUB) in hospitalized children from 2010 to 2020.
  • Among 343 patients, FLUA was more prevalent (75.8%) than FLUB (24.2%), with FLUB linked to higher rates of headache and abdominal pain, particularly in the 3-9 age group.
  • Children aged 0-2 with FLUA had a significantly higher chance of being admitted to the pediatric intensive care unit (PICU) compared to those with FLUB, emphasizing the need for increased attention for this age group.
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Introduction: Cystic fibrosis transmembrane conductance regulator (CFTR) modulator drugs target the underlying defect and improve CFTR function. They are a part of standard care in many countries, but not all patients are eligible for these drugs due to age and genotype. Here, we aimed to determine the characteristics of non-eligible patients for CFTR modulators in the CF registry of Turkey (CFRT) to highlight their clinical needs.

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Introduction: Flexible bronchoscopy is a valuable method in the diagnosis and treatment of respiratory tract diseases in children. This study aimed to examine the indications for and results of flexible bronchoscopy in children.

Materials And Methods: The study included patients aged 0-18 years who underwent flexible bronchoscopy between 1 January 2017 and 31 December 2022.

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Oral immunotherapy (OIT) has gained popularity recently for IgE-mediated food allergy. Omalizumab (OMZ) has been used in patients (10-20%) who have too severe/frequent allergic reactions (AR) to continue OIT, to reduce these reactions. In this study, it was aimed to compare two groups of patients who completed OIT with and without OMZ and to seek determinants predicting the need of this treatment.

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The childhood interstitial lung diseases (chILD) Turkey registry (chILD-TR) was established in November 2021 to increase awareness of disease, and in collaboration with the centers to improve the diagnostic and treatment standards. Here, the first results of the chILD registry system were presented. In this prospective cohort study, data were collected using a data-entry software system.

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Background: Hereditary angioedema with C1 inhibitor deficiency (HAE-C1INH) is caused by dysfunctional C1-INH protein due to mutations in the SERPING1 gene encoding C1-INH. Marfan syndrome is a genetic connective tissue disease that affects the cardiovascular and ocular systems along with the skeletal system. In this case, we present the successful treatment of post-pericardiotomy syndrome unresponsive to classical therapy, which has not been described in the literature.

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Objective: The cut-off values for the skin prick test diameters and cow's milk-specific IgE measurements are used to predict the result of the oral food challenge test for the diagnosis of cow's milk allergy. This study aimed to determine the diagnostic values of skin prick test and cow's milk-specific IgE according to age groups and compare the diagnostic powers of these 2 methods.

Materials And Methods: In total, 153 children who had a preliminary diagnosis of cow's milk allergy were evaluated.

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Objective: Adverse reactions, which are mostly local and rarely systemic, can be seen during subcutaneous immunotherapy (SCIT). It was not possible to continue SCIT at times due to systemic reactions. The purpose of the present study was to identify the incidence and risk factors associated with adverse reactions during subcutaneous allergen-specific immunotherapy (AIT).

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Background: Oral immunotherapy (OIT) is a novel allergen-specific treatment for food allergies.

Objective: To investigate the effect of OIT on blocking antibodies, T cell regulation, and cytokine response during immunoglobulin (Ig)E-mediated cow's milk allergy (CMA) treatment.

Methods: A total of 59 children with IgE-mediated CMA who were followed in pediatric allergy outpatient clinic and 18 healthy children were included.

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Severe immunglobuline E (IgE)-mediated reactions during oral immunotherapy (OIT) are major obstacles to treatment. The present study aimed to evaluate and identify clinical and laboratory biomarkers of adverse events during OIT among children with cow's milk (CM) allergy. Eighty-six children older than 36 months who had undergone OIT with milk were enrolled.

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  • Dynamic hyperinflation (DH) significantly affects exercise performance in patients with obstructive lung diseases, but its role in children with bronchiectasis (BE) was previously unexplored.
  • In a study with 40 children, about 50% experienced DH during a six-minute walk test, showing a notable reduction in inspiratory capacity after exertion, though it didn't correlate with other clinical indicators.
  • Peripheral muscle strength emerged as a key factor affecting exercise capacity, with strong correlations found between muscle strength metrics and the distance covered during the walk test.
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  • The study aimed to compare the effectiveness of high-flow nasal cannula oxygen (HFNCO) versus low-flow oxygen (LFO) in young children with bronchiolitis requiring oxygen therapy.
  • Results indicated that HFNCO led to significantly faster recovery in heart rate, respiratory rate, and clinical respiratory scores compared to LFO.
  • The findings suggest that HFNCO may offer improved respiratory support, but further research is necessary to fully understand its clinical benefits.
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Background: Cystic fibrosis (CF) registries play an essential role in improving disease outcomes of people with CF. This study aimed to evaluate the association of newly established CF registry system in Turkey on follow-up, clinical, growth, treatment, and complications of people with this disease.

Methods: Age at diagnosis, current age, sex, z-scores of weight, height and body mass index (BMI), neonatal screening results, pulmonary function tests, history of meconium ileus, medications, presence of microorganisms, and follow-up were evaluated and compared to data of people with CF represented in both 2017 and 2019 registry data.

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Objective: Cow's milk (CM) contains some proteins capable of causing an allergic reaction in a sensitized individual and one of the most common causes of food allergy in childhood. Most of the patients will develop tolerance by the age of 3. In this study, we aimed to evaluate sensitivity to CM allergen components as well as goat's milk (GM) and sheep's milk cross reactions in cow's milk allergic (CMA) patients and to figure out the risk factors for tolerance non-development.

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  • Identifying risk factors for asthma in Turkish children with recurrent wheezing is challenging; this study analyzed 651 children (200 girls, 451 boys) to explore these factors.
  • Among the children studied, 57.7% were diagnosed with asthma; the main associated factors included family history of atopy, parents' asthma, and respiratory symptoms between wheezing attacks, while factors like maturity and passive smoking were not linked to asthma.
  • The study highlighted the modified asthma predictive index (mAPI) and the modified PIAMA score as useful but limited tools in predicting asthma, emphasizing the need to differentiate it from other chronic pediatric conditions.
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Background: Despite the availability of cystic fibrosis (CF) screening countrywide, diagnostic delay is still a crucial issue. The objectives of this study were to explore the stages of the NBS process, determine the risk factors associated with diagnostic delay and evaluate parent anxiety and experience throughout the process.

Methods: This is a multicenter cross-sectional study.

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Introduction: The diagnosis of asthma is still a difficult problem in cystic fibrosis. There is no consensus on how to define "CF asthma". The aim of this study was to determine the role of bronchodilator response and laboratory evidence of allergy in "CF asthma".

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Objective: Characterization of wheezing phenotypes in children might help to identify the underlying mechanisms through which asthma occurs. In our study, we aimed to describe wheezing phenotypes in Turkish children and to identify risk factors according to phenotypes.

Methods: 651 wheezy children were evaluated and 5 wheezing phenotypes were described according to age of onset, atopy and persistence at 6 years of age and risk factors were identified.

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  • The study aims to investigate if having multiple viral infections increases the risk of severe lower respiratory tract infections (LRTI) in children.
  • The researchers hypothesize that children with viral coinfections are more likely to be admitted to the intensive care unit (ICU) compared to those infected with only one virus.
  • This is a retrospective, observational study that analyzes data from a 10-year period, focusing on hospitalized children aged 1 to 60 months with LRTI.
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  • The impulse oscillometry system (IOS) is a noninvasive test gaining traction in evaluating pulmonary function in cystic fibrosis (CF) patients, despite not being widely adopted.
  • In a study analyzing data from January 2018 to February 2019, IOS was shown to correlate well with traditional spirometry in assessing clinical conditions like exacerbations and treatment responses in CF patients.
  • The findings suggest that while IOS is not a replacement for spirometry, it serves as a valuable alternative for monitoring CF patients’ lung health.
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Aim: Recurrent wheezing is a common problem in preschool children.It is classified into two groups because there can be many reasons for wheeze: typical and atypical. The aim of this study was to identify the general features of atypical wheezy children.

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Recombinant factor VIIa (rFVIIa) is a highly purified recombinant protein. It is approved for the treatment and prevention of bleeding episodes associated with congenital factor VII deficiency, congenital hemophilia with inhibitors, and Glanzmann's thrombasthenia. The most commonly reported adverse events are thrombolytic in nature.

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  • Oral immunotherapy can effectively increase the tolerance levels in children with cow's milk allergy, making it a viable treatment option in pediatric allergy clinics.
  • A study involving 42 patients showed that the average age to start treatment was around 3.3 years, with mild to moderate adverse reactions occurring in 38% of cases during the therapy.
  • Factors like age and specific immunoglobulin-E levels didn't significantly predict adverse reactions, but patients with a history of anaphylaxis experienced more reactions during the treatment.
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Background/aim: Acute exacerbations and chronic inflammation are risk factors for cardiovascular disease (CVD) in cystic fibrosis (CF) patients. The aim of this study was to investigate the effects of acute exacerbation therapy on arterial stiffness in children with CF.

Materials And Methods: Augmentation index (Aix) and pulse wave velocity (PWV) were measured before and after treatment and 1 month after the end of treatment in patients with acute exacerbation.

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