Retrospective study of incidence/prevalence of pigmentary maculopathy and retinopathy in patients receiving pentosan polysulfate sodium.

Purpose: To evaluate prevalence and incidence rates of pigmentary maculopathy and retinopathy (PM/PR), and visual acuity (VA) changes in patients exposed to pentosan polysulfate sodium (PPS) and in patients with interstitial cystitis (IC) not exposed to PPS.

Methods: This is a retrospective cohort study (January 2015-March 2021) which included adult de-identified patients from the American Academy of Ophthalmology IRIS® Registry (Intelligent Research in Sight) and Komodo Health database. Three patient cohorts were identified: two PPS-exposed patient cohorts, and Non-PPS-exposed IC patient cohort.

Temperature stabilization of a lab space at 10 mK-level over a day.

Temperature fluctuations over long time scales (≳ 1 h) are an insidious problem for precision measurements. In optical laboratories, the primary effect of temperature fluctuations is drifts in optical circuits over spatial scales of a few meters and temporal scales extending beyond a few minutes. We present a lab-scale environment temperature control system approaching 10 mK-level temperature instability across a lab for integration times above an hour and extending to a day.

The role of substance misuse and sexual victimization history on sexual violence risk perception in men who have sex with men: A novel paradigm.

Objective: Sexual victimization (SV) is common among men who have sex with men (MSM) as is dating and sexual networking (DSN) app use. We developed a novel laboratory paradigm ("G-Date") of sexual violence risk perception in DSN app environments and explored its validity and the role of substance misuse and SV history on sexual violence risk perception.

Method: Using convenience sampling, we recruited 145 MSM to use G-Date to interact with two bogus speed dates whose responses were scripted to be risky or non-risky.

Assessment of Sexual Violence Risk Perception in Men Who Have Sex With Men: Proposal for the Development and Validation of "G-Date".

Background: Sexual violence (SV) is a significant problem for sexual minorities, including men who have sex with men (MSM). The limited research suggests SV is associated with a host of syndemic conditions. These factors tend to cluster and interact to worsen one another.

Subcision with and without suction for acne scars: a split-faced, rater-blinded randomized control trial.

Therapeutic options for acne scars include subcision and suction with microdermabrasion, but these treatment modalities have not been studied in conjunction. To compare effectiveness of subcision alone versus subcision with suction for the treatment of facial acne scars. Randomized, split-faced, evaluator-blinded control trial.

Comparing researchers' degree of dichotomous thinking using frequentist versus Bayesian null hypothesis testing.

A large amount of scientific literature in social and behavioural sciences bases their conclusions on one or more hypothesis tests. As such, it is important to obtain more knowledge about how researchers in social and behavioural sciences interpret quantities that result from hypothesis test metrics, such as p-values and Bayes factors. In the present study, we explored the relationship between obtained statistical evidence and the degree of belief or confidence that there is a positive effect in the population of interest.

Incidence of fibrosing colonopathy with pancreatic enzyme replacement therapy in patients with cystic fibrosis.

Background: High daily doses of pancreatic enzyme replacement therapy (PERT) were historically associated with risk of fibrosing colonopathy (FC) in people with cystic fibrosis (pwCF), leading to development of PERT dosing guidelines and reformulated products. This study quantified incidence of FC in pwCF treated with PERT following those measures.

Methods: This large prospective cohort study included eligible pwCF enrolled in the Cystic Fibrosis Foundation Patient Registry with ≥1 clinic visit in 2012-2014 and follow-up through 2020.

No evidence of resistance to itraconazole in a prospective real-world trial of dermatomycosis in India.

Background: The prevalence of superficial fungal infections in India is believed to have increased substantially in the past decade. We evaluated the treatment outcomes and risk factors associated with clinical response to a treatment course of itraconazole for the management of dermatomycosis in India.

Methods: In this real-world, prospective pilot study (August 2019 to March 2020), adult participants (18-60 years), diagnosed with T.

Risk of retinal detachment and exposure to fluoroquinolones, common antibiotics, and febrile illness using a self-controlled case series study design: Retrospective analyses of three large healthcare databases in the US.

Objective: The risk of retinal detachment (RD) following exposure to fluoroquinolone (FQ) has been assessed in multiple studies, however, results have been mixed. This study was designed to estimate the risk of RD following exposure to FQ, other common antibiotics, and febrile illness not treated with antibiotics (FINTA) using a self-controlled case series (SCCS) study design to reduce risk of confounding from unreported patient characteristics.

Design: Retrospective database analysis-SCCS.

Common, uncommon, and novel applications of random forest in psychological research.

Recent reform efforts have pushed toward a better understanding of the distinction between exploratory and confirmatory research, and appropriate use of each. As some utilize more exploratory tools, it may be tempting to employ multiple linear regression models. In this paper, we advocate for the use of random forest (RF) models.

Baseline risk characterization of early versus later adopters of long-acting paliperidone palmitate formulations.

Early Post-Marketing Phase Vigilance (EPPV) is a unique system that encourages reporting of serious adverse reactions for medications newly introduced to Japan. When a once-monthly paliperidone palmitate formulation (PP1M) was introduced in Japan in 2013, EPPV detected a signal of increased mortality, but this signal was not subsequently confirmed. To clarify whether that signal reflected increased adverse event reporting or an atypically high baseline mortality risk among early adopters of PP1M, we evaluated the baseline risk characteristics of early, mid, and later adopters of PP1M in a Japanese database and did a similar evaluation of PP1M and the three-monthly formulation (PP3M) in two US databases.

Seeing the impossible: Visualizing latent variable models with flexplavaan.

Latent variable models (LVMs) are incredibly flexible tools that allow users to address research questions they might otherwise never be able to answer (McDonald, 2013). However, one major limitation of LVMs is evaluating model fit. There is no universal consensus about how to evaluate model fit, either globally or locally.

Flexplot: Graphically-based data analysis.

The human visual processing system has enormous bandwidth, able to interpret vast amounts of data in fractions of a second (Otten et al., 2015). Despite this amazing ability, there is a troubling lack of graphics in scientific literature (Healy & Moody, 2014), and the graphics most traditionally used tend to bias perception in unintentional ways (Weissgerber et al.

Understanding the exploratory/confirmatory data analysis continuum: Moving beyond the "replication crisis".

In light of the "replication crisis," some advocate for stricter standards and greater transparency in research methods. These efforts push toward a data analysis approach called "confirmatory data analysis" (CDA; see Wagenmakers et al., 2012).

Risk of aortic aneurysm and dissection following exposure to fluoroquinolones, common antibiotics, and febrile illness using a self-controlled case series study design: Retrospective analyses of three large healthcare databases in the US.

Objective: Recent observational studies suggest increased aortic aneurysm or dissection (AAD) risk following fluoroquinolone (FQ) exposure but acknowledge potential for residual bias from unreported patient characteristics. The objective of our study is to evaluate the potential association between FQ, other common antibiotics and febrile illness with risk of AAD using a self-controlled case series (SCCS) study design.

Design: Retrospective database analysis-SCCS.

Medications for attention-deficit/hyperactivity disorder in Japan: A retrospective cohort study of label compliance.

Aim: To assess label compliance in prescription of medications approved for treatment of attention-deficit/hyperactivity disorder (ADHD) in Japan at the time of this study: methylphenidate (MPH), atomoxetine, and guanfacine.

Methods: Retrospective descriptive study was conducted in prevalent-user cohorts from the Japan Medical Data Center database. Patients who were prescribed a study drug between January 1, 2013 and September 30, 2018 and were in the database for ≥30 days were included.

Beliefs related to health care incentives: Comparison of substance use disorder treatment providers, medical treatment providers, and a public sample.

This study surveyed substance use disorder (SUD) treatment providers, medical treatment providers, and a public sample about beliefs regarding health care incentives to explore differences among the groups and across health disorders for which research has demonstrated incentives improve outcomes. Six hundred participants (n = 200/group) completed the Provider Survey of Incentives. The study found between group differences for positive and negative beliefs.

Understanding patient journey in ulcerative colitis prior to biologic initiation: a 5-year exploration.

Background: There has been a more pronounced shift toward earlier, more aggressive therapies in Crohn's disease than in ulcerative colitis (UC). The aim of this study was to describe the pre-biologic treatment and health care experience, including co-morbidities and overall health care utilization, for UC patients who initiated biologic therapies, in the 5 years prior to the initiation of the first biologic agent.

Methods: UC patients who initiated a biologic agent approved for UC between 9/15/2005 and 1/30/2018 were identified from the IBM® MarketScan® Commercial Database, a large US database.

A graph for every analysis: Mapping visuals onto common analyses using flexplot.

For decades, statisticians and methodologists have insisted researchers utilize graphical analysis much more heavily. Despite cogent and passionate recommendations, there has been no graphical revolution. Instead, researchers rely heavily on misleading graphics that violate visual processing heuristics.

Stroke Risk Among Elderly Users of Haloperidol and Typical Antipsychotics Versus Atypical Antipsychotics: A Real-World Study From a US Health Insurance Claims Database.

Background: We estimated stroke risk associated with new exposure to haloperidol, or any typical antipsychotic, versus atypical antipsychotic among patients aged ≥65 years regardless of dementia status.

Methods: IBM MarketScan Medicare Supplemental Database data (January 1, 2001 to December 31, 2017) were used. Stroke risk for new users of typical antipsychotics (T1 cohort) or haloperidol (T2 cohort) was compared with new users of atypical antipsychotics (C1 cohort) aged ≥65 years.

The problem of measurement bias in comparing selected subgroups.

Estimates of subgroup differences are routinely used as part of a comprehensive validation system, and these estimates serve a critical role, including evaluating adverse impact. Unfortunately, under direct range restriction, a selected mean ( ) is a biased estimator of the population mean as well as the selected true score mean . This is due partly to measurement bias.

The Eight Steps of Data Analysis: A Graphical Framework to Promote Sound Statistical Analysis.

Data analysis is a risky endeavor, particularly among people who are unaware of its dangers. According to some researchers, "statistical conclusions validity" threatens all research subjected to the dark arts of statistical magic. Although traditional statistics classes may advise against certain practices (e.

Channeling Bias in the Analysis of Risk of Myocardial Infarction, Stroke, Gastrointestinal Bleeding, and Acute Renal Failure with the Use of Paracetamol Compared with Ibuprofen.

Introduction: Observational studies estimating severe outcomes for paracetamol versus ibuprofen use have acknowledged the specific challenge of channeling bias. A previous study relying on negative controls suggested that using large-scale propensity score (LSPS) matching may mitigate bias better than models using limited lists of covariates.

Objective: The aim was to assess whether using LSPS matching would enable the evaluation of paracetamol, compared to ibuprofen, and increased risk of myocardial infarction, stroke, gastrointestinal (GI) bleeding, or acute renal failure.