Publications by authors named "Field N"

This study examined reciprocal relations between two dimensions of peer status, likability and popularity, and two dimensions of empathy, empathic concern and perspective taking, across adolescence. A school-based sample of 893 ( = 12.60, = 0.

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While the impact of social restrictions on sexual and romantic life early in the COVID-19 pandemic has been widely studied, little is known about impacts beyond the initial months. We analyzed responses from 2,098 British adults (aged 18-59) taking part in the Natsal-COVID study (Waves 1 and 2). Participants were recruited via a web panel and surveyed twice: four months and one year after the start of the UK's first national lockdown (July 2020 and March 2021).

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Clinicians may face an array of challenges in conducting fetal neurological consultations including prognostic uncertainty, a lack of training in fetal counseling, and limited opportunity to build rapport with families. In this setting, it is critical to employ high-quality, family-centered care to allow expectant parents to make informed decisions. Despite the challenges and gravity of these consultations, there remains limited data outlining best conduct and communication practices.

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Long-distance transport and associated fasting of unweaned calves have the potential to compromise the animals' welfare. This observational study aimed to determine how transport and fasting durations impacted the physiology and health of 115 transported calves in three transport groups; IRE (n = 20, mean age 29.8d; short road transport (~ 29 h incl.

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Introduction: The Flow Re-direction Endoluminal Device (FRED) is a novel flow diverter with a unique double stent design, with an inner stent composed of 48 nitinol wires, and an outer stent with 16 nitinol wires. It is designed for endovascular cerebral aneurysm treatment, although, limited data exist regarding in-stent stenosis (ISS) rates associated with FRED devices.

Methods: A registry encompassing two North American comprehensive stroke centers was the base of this study.

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Article Synopsis
  • The National Surveys of Sexual Attitudes and Lifestyles (Natsal) aim to estimate the prevalence of sexually transmitted infections (STIs) in Britain through biosampling, evaluating methods for acceptability and response rates.
  • Two pilot studies were conducted with participants aged 16-59, who provided urine or vaginal swab samples either during face-to-face interviews or remotely, with feedback collected to assess the processes.
  • Out of 261 participants, 62% consented to biosampling, with a higher sample return from face-to-face interviews, indicating general acceptability of the biosampling methods used for STI testing in the national survey.
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Background: Uptake of human papillomavirus (HPV) vaccination is generally high in high-income countries with school-based vaccination programmes; however, lower uptake in certain population subgroups could continue pre-immunisation inequalities in cervical cancer.

Methods: Six electronic databases were searched for quantitative articles published between 1 September 2006 and 20 February 2023, which were representative of the general population, with individual-level data on routine school-based vaccination (with >50% coverage) and sociodemographic measures. Titles, abstracts and full-text articles were screened for eligibility criteria and assessed for bias.

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  • Recent research suggests recreational marijuana may negatively impact cerebrovascular issues, but its effects on arteriovenous malformations (AVMs) outcomes are unclear.
  • The study analyzed data from nearly 46,500 adult patients with AVMs, focusing on drug use (including marijuana) and its association with AVM ruptures, complications, and hospital stays.
  • Results indicate that tobacco and cannabis may have a protective effect against AVM rupture and are associated with lower complications and hospital stays, while stimulant use increases the risk of ruptured AVMs and higher mortality.
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  • * A study analyzed 101 patients across four US centers, finding low complication rates (5.9% thromboembolic events and 0% procedure-related mortality), and satisfactory aneurysm occlusion at follow-ups (58% at 6 months and 74.8% at 6-12 months).
  • * The results suggest that FRED X stenting is a safe and effective option for treating unruptured intracranial aneurysms, although more long-term data is needed for comprehensive evaluation.*
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We aimed to characterize parents' perspectives on the value of and opportunities to improve conferences between parents of critically ill infants and the health care team. The parent perspective on the value of family conferences in the intensive care unit is not well characterized. In this descriptive qualitative study, parents of infants with neurological conditions in the intensive care unit at a U.

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Individuals befriend others who are similar to them. One important source of similarity in relationships is similarity in felt emotion. In the present study, we used novel methods to assess whether greater similarity in the multivoxel brain representation of affective stimuli was associated with adolescents' proximity within real-world school-based social networks.

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  • Genetic mutations and epigenetic changes work together to promote cancer by impacting cancer-related genes, particularly the SWI/SNF complex members SMARCA4 and SMARCA2.
  • The simultaneous loss of both SMARCA4 and SMARCA2 is notably lethal and is a distinctive characteristic in specific cancers like early-onset ovarian cancer and other rare tumors.
  • The review explores the common clinical and molecular traits of cancers with this dual loss, the mechanisms leading to their dysfunction, and potential targeted therapies for these conditions.*
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The sounds we experience in our everyday communication can vary greatly in terms of level and background noise depending on the environment. Paradoxically, increasing the sound intensity may lead to worsened speech understanding, especially in noise. This is known as the "Rollover" phenomenon.

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Background: Parents of neonates with seizures report persistent symptoms of depression, anxiety, and posttraumatic stress. We aimed to characterize the parent experience of caring for children impacted by neonatal seizures, including longitudinal assessment across childhood.

Methods: This prospective, observational, multicenter study was conducted at Neonatal Seizure Registry (NSR) sites in partnership with the NSR Parent Advisory Panel.

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SWI/SNF (SWItch/Sucrose Non-Fermentable) is the most frequently mutated chromatin-remodelling complex in human malignancy, with over 20% of tumours having a mutation in a SWI/SNF complex member. Mutations in specific SWI/SNF complex members are characteristic of rare chemoresistant ovarian cancer histopathological subtypes. Somatic mutations in , encoding one of the mutually exclusive DNA-binding subunits of SWI/SNF, occur in 42-67% of ovarian clear cell carcinomas (OCCC).

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Background: During the COVID-19 pandemic, online sexual health service delivery increased across Britain. We investigated inequalities in STI testing access and methods of access during the first year of the pandemic.

Methods: Natsal-COVID, an online-survey of people 18-59 years in Britain, explored sexual health experiences in the first year of the pandemic.

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  • Human microbiota begins forming at birth, influenced by maternal and environmental microbes, with core theories suggesting that initial colonizers impact community development.
  • Research involving 1,288 UK neonates revealed three distinct gut microbiota profiles, each led by specific microbial species affected by factors like maternal age and ethnicity.
  • Bifidobacteria, especially B. breve, were identified as key players in fostering stable gut microbiota and resisting pathogens, supporting their importance as primary colonizers in early life.
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Objective: The modified Brain Injury Guidelines (mBIG) were developed to improve care of patients with traumatic brain injury (TBI). This study aimed to assess if utilization of mBIG by neurosurgeons would improve TBI patient throughput at a Level I trauma center, particularly for patients meeting mBIG 1 criteria.

Methods: This was a retrospective observational study at a Level I trauma center.

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  • Congenital cytomegalovirus (cCMV) is prevalent globally, with 85%-90% of infected infants showing no symptoms at birth, but 10%-15% may face issues like sensorineural hearing loss later on.
  • A review of studies focused on the neurodevelopmental outcomes of asymptomatic cCMV (AcCMV) in children found that they generally performed better than symptomatic cCMV children, but the understanding of their long-term neurodevelopment is still unclear.
  • Most studies showed AcCMV children had comparable outcomes to CMV-uninfected children, though limitations like a lack of control groups and inconsistent definitions hindered the findings; further research with standardized methods is needed.
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  • The study explores gepotidacin, a new treatment for gonorrhea, and investigates genetic changes in the GyrA and ParC targets of gonococci using a large dataset of genomes.
  • Key findings show that alterations at GyrA position A92 are rare, while changes at ParC position D86 are more common, but neither type resulted in resistance to gepotidacin.
  • The authors emphasize the importance of monitoring potential antimicrobial resistance and using effective MIC testing methods to ensure gepotidacin remains effective against gonorrhea.
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Background: Stent development has focused recently on low-profile, self-expandable stents compatible with 0.0165 inch microcatheters. The LVIS EVO is the second-generation version of the Low-Profile Visualized Intraluminal Support (LVIS) with improved visibility and resheathability.

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Objectives: The utility of whole genome sequencing (WGS) to inform sexually transmitted infection (STI) patient management is unclear. Timely WGS data might support clinical management of STIs by characterising epidemiological links and antimicrobial resistance profiles. We conducted a systematic review of clinical application of WGS to any human pathogen that may be transposable to gonorrhoea.

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A distinguishing feature of eukaryotes is the presence of a nuclear envelope (NE) and endomembrane system. The NE is a double-membrane system that surrounds chromatin and is continuous with the endoplasmic reticulum (ER). This interface is crucial in various processes such as calcium signaling and ER-associated degradation.

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Background: Continuous glucose monitors provide detailed information regarding glycemic control in pregnant patients with type 1 diabetes. Little data have been published examining the association between continuous glucose monitor parameters and perinatal outcomes among gravidas with type 1 diabetes using continuous glucose monitors.

Objective: This study aimed to examine the association between perinatal outcomes and time-in-range as assessed by continuous glucose monitors used in pregnant individuals with type 1 diabetes.

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