Publications by authors named "Fidelia Berenice Prayugo"
Breast cancer is one of the leading deaths in all kinds of malignancies; therefore, it is important for early detection. At the primary tumor site, tumor cells could take on mesenchymal properties, termed the epithelial-to-mesenchymal transition (EMT). This process is partly regulated by members of the cadherin () family of genes, and it is an essential step in the formation of metastases.
View Article and Find Full Text PDFBreast cancer remains the most common malignant cancer in women, with a staggering incidence of two million cases annually worldwide; therefore, it is crucial to explore novel biomarkers to assess the diagnosis and prognosis of breast cancer patients. NIMA-related kinase (NEK) protein kinase contains 11 family members named NEK1-NEK11, which were discovered from ; however, the role of NEK family genes for tumor development remains unclear and requires additional study. In the present study, we investigate the prognosis relationships of NEK family genes for breast cancer development, as well as the gene expression signature via the bioinformatics approach.
View Article and Find Full Text PDFArticle Synopsis
- Colorectal cancer (CRC) is a leading cause of cancer-related deaths, and early detection is crucial, especially with rising obesity linked to poor dietary habits.
- Fatty acid-binding proteins (FABPs) play essential roles in metabolism and inflammation, but their function in CRC development remains unclear, prompting a bioinformatics analysis of their gene expression across various platforms.
- The study found that overexpression of the FABP family in CRC cells is associated with poor patient prognosis, indicating that high levels of these proteins could serve as potential early biomarkers for CRC detection.