Efficacy and safety of tigecycline compared with vancomycin or linezolid for treatment of serious infections with methicillin-resistant Staphylococcus aureus or vancomycin-resistant enterococci: a Phase 3, multicentre, double-blind, randomized study.

Introduction: Methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant enterococci (VRE) are causing serious nosocomial infections. Tigecycline was evaluated in hospitalized patients with MRSA or VRE infection.

Patients And Methods: A randomized (3:1), double-blind, multicentre, Phase 3 study compared the safety and efficacy of tigecycline with vancomycin or linezolid in hospitalized patients with MRSA or VRE infection, respectively.

[Retroperitoneal postoperative necrotizing fasciitis].

This is a report on clinical experience had with 17 patients presenting necrotizing fasciitis--a complication ever more frequently encountered. The case material is distributed in two group differing by origin and clinical course of the complication. In group one (n = 11) it is a matter of postoperative development of postoperative complication, consistent with the classical "per continuitatem" and "per contiguitatem" mechanisms, while in group two (n = 6) the process originates, evolves and speads within the retroperitoneal space proper.

Fournier's Gangrene: a clinical and bacteriological study.

Bacteriological studies were conducted in patients presenting with Fournier's Gangrene (FG) in our Department during a period of 11 years. These studies showed high numbers of anaerobes (96%) and the ratio of aerobes to anaerobes was reported to be 1.4: 3.

Bilophila wadsworthiain brain abscess: case report.

A case of a patient with a 20-year history of chronic otitis media complicated by cholesteatoma and brain abscess is described. A CT scan with contrast material showed three abscess cavities in the right cerebellar hemisphere. A culture from a specimen of the cholesteatoma yielded a significant amount of growth of Bilophila wadsworthia, Bacteroides fragilis and Prevotella oris and a moderate growth of alpha-streptococci and Staphylococcus simulans.

[Problems in the surgical treatment of diabetic gangrene].

Parallel to life expectancy prolongation and constantly improving life style of diabetic patients in this country, observed during the last decade, the problems relating to complications in diabetes become of primary importance. From 60 to 70 per cent of the diabetics with foot ulcerations have neuropathy. The serious forms of nerve involvement appear to be a major cause of lower extremity amputation.

[Postoperative anaerobic sepsis].

As shown by clinical practice, postoperative anaerobic sepsis is a complication more common than usually thought of or microbiologically verified. The exceptionally difficult microbiological verification, regardless of the fact that original registered transport media are employed, is the underlying cause of obligate non-spore forming microorganisms from hemoculture being demonstrated in four patients only. In all of them Bacteroides fragilis is isolated and identified.

[Clostridial surgical infection].

An ever increasing attention of clinicists is being focused on nontraumatic clostridal surgical infections. Personal clinical case material consisting of 390 patients with microbiologically proved clostridial infection are subjected to clinical and microbiological investigations aimed at establishing the nature of the infective process. In 377 patients (group one) signs of mixed aerobic-anaerobic polyinfection are clinically documented, fully confirmed by the comprehensive microbiological examinations performed.

[Postoperative necrotizing fasciitis of the anterior abdominal wall].

Postoperative necrotizing fasciitis of the anterior abdominal wall is a serious and life-endangering complication of an acute progressive synergistic infective process. There is an absolute increase in its incidence rate attributable to a number of situations in modern life. Morphological and clinical studies are carried out on personal case material of 28 patients, followed up over a 3-year period.