Developing multitarget coumarin based anti-breast cancer agents: synthesis and molecular modeling study.

A new series of 7-substituted coumarin scaffolds containing a methyl ester moiety at the C-position were synthesized and tested for their in vitro anti-proliferative activity against MCF-7 and MDA-MB-231 breast cancer cell lines using Doxorubicin (DOX) as reference. Compounds 2 and 8 showed noticeable selectivity against MCF-7 with IC = 6.0 and 5.