New halogenated chalcones with cytotoxic and carbonic anhydrase inhibitory properties: 6-(3-Halogenated phenyl-2-propen-1-oyl)-2(3H)-benzoxazolones.

In this study, novel halogenated chalcones, 6-(3-halogenated phenyl-2-propen-1-one)-2(3H)-benzoxazolones (2a-n), were synthesized for the first time (except 2a), and their chemical structures were characterized by H nuclear magnetic resonance (NMR), C NMR, and high-resolution mass spectrometry spectra. Cytotoxic activities and carbonic anhydrase (CA) inhibitory effects of the compounds were studied to identify new possible drug candidate molecules. Cytotoxicity results pointed out that compound 2m, 6-[3-(3-bromophenyl)-2-propenoyl]-2(3H)-benzoxazolone, had the highest cytotoxicity (CC ) and potency selectivity expression (PSE) values.

Synthesis, cytotoxicities, and carbonic anhydrase inhibition potential of 6-(3-aryl-2-propenoyl)-2()-benzoxazolones.

In this study, new chalcone compounds having the chemical structure of 6-(3-aryl-2-propenoyl)-2()-benzoxazolones () were synthesised and were characterised by H-NMR, C-NMR, and HRMS spectra. Cytotoxic and carbonic anhydrase (CA) inhibitory effects of the compounds were investigated. Cytotoxicity results pointed out that compound , 6-[3-(4-trifluoromethylphenyl)-2-propenoyl]-3-benzoxazol-2-one, showed the highest cytotoxicity (CC) and potency-selectivity expression (PSE) value, and thus can be considered as a lead compound of this study.