Postoperative complications in the Tube Versus Trabeculectomy (TVT) study during five years of follow-up.

Purpose: To describe postoperative complications encountered in the Tube Versus Trabeculectomy (TVT) Study during 5 years of follow-up.

Design: Multicenter randomized clinical trial.

Settings: Seventeen clinical centers.

Head-down posture induces PERG alterations in early glaucoma.

Purpose: To probe susceptibility of retinal ganglion cells (RGC) to physiological stressors associated with moderate head-down body tilt in patients with suspicion of glaucoma or early manifest glaucoma (EMG).

Methods: One hundred nine subjects with best corrected visual acuity (BCVA) ≥ 20/20 and no disease other than glaucoma [glaucoma suspects (GS)=79, EMG=14, normal controls (NC)=16 and comparable age range were tested. Noncontact intraocular pressure (IOP), pattern electroretinogram (PERG), and brachial blood pressure/heart rate measurements were performed in 3 consecutive conditions (∼0038 min apart): seated (baseline), -10-degree whole body head-down tilt (HDT), and seated again (recovery).

Glaucoma Progression Analysis software compared with expert consensus opinion in the detection of visual field progression in glaucoma.

Purpose: To compare the results of Glaucoma Progression Analysis (GPA, Carl Zeiss Meditec, Dublin, CA) to subjective expert consensus in the detection of glaucomatous visual field progression.

Design: Retrospective, observational case series.

Participants: We included 100 eyes of 83 glaucoma patients.

Pattern electroretinogram progression in glaucoma suspects.

Purpose: To prospectively monitor progressive changes of retinal ganglion cell function in early glaucoma using the pattern electroretinogram (PERG).

Methods: Fifty-nine patients enrolled as glaucoma suspects were observed untreated over an average of 5.7±1.

Quantitative imaging of retinal pigment epithelial detachments using spectral-domain optical coherence tomography.

Purpose: To evaluate the reproducibility of area and volume measurements of retinal pigment epithelium detachments (PEDs) in eyes of patients with age-related macular degeneration using spectral-domain optical coherence tomography imaging and a novel automated, quantitative algorithm.

Design: Prospective study to evaluate a diagnostic technology.

Methods: Patients with PEDs associated with age-related macular degeneration underwent spectral-domain optical coherence tomography imaging.

Macular ganglion cell-inner plexiform layer: automated detection and thickness reproducibility with spectral domain-optical coherence tomography in glaucoma.

Purpose: To demonstrate the capability of SD-OCT to measure macular retinal ganglion cell-inner plexiform layer (GCIPL) thickness and to assess its reproducibility in glaucomatous eyes.

Methods: Fifty-one glaucomatous eyes (26 mild, 11 moderate, 14 severe) of 51 patients underwent macular scanning using the Cirrus HD-OCT (Carl Zeiss Meditec, Dublin, CA) macula 200×200 acquisition protocol. Five scans were obtained on 5 days within 2 months.

Gene therapy for leber congenital amaurosis caused by RPE65 mutations: safety and efficacy in 15 children and adults followed up to 3 years.

Objective: To determine the safety and efficacy of subretinal gene therapy in the RPE65 form of Leber congenital amaurosis using recombinant adeno-associated virus 2 (rAAV2) carrying the RPE65 gene.

Design: Open-label, dose-escalation phase I study of 15 patients (range, 11-30 years of age) evaluated after subretinal injection of the rAAV2- RPE65 vector into the worse-functioning eye. Five cohorts represented 4 dose levels and 2 different injection strategies.

Effects of changing operators and instruments on time-domain and spectral-domain OCT measurements of retinal nerve fiber layer thickness.

Background And Objective: To determine the amount of interoperator and interinstrument variability introduced into retinal nerve fiber layer (RNFL) thickness measured with Stratus OCT and Cirrus HD-OCT (Carl Zeiss Meditec, Dublin, CA) in normal and glaucomatous eyes.

Patients And Methods: Thirty-seven eyes from 37 subjects (20 normal and 17 with glaucoma) were included in the study. Each eye was scanned with one Stratus OCT and one Cirrus OCT by two operators.

Natural history of drusen morphology in age-related macular degeneration using spectral domain optical coherence tomography.

Purpose: To characterize the natural history of drusen using spectral-domain optical coherence tomography (SD-OCT) imaging of eyes from patients with nonexudative age-related macular degeneration (AMD).

Design: Prospective, longitudinal, natural history study.

Participants: We included 143 eyes of 100 patients with at least 6 months of follow-up.

Prevalence and risk factors of dry eye syndrome in a United States veterans affairs population.

Purpose: To evaluate the prevalence of dry eye syndrome (DES) and its associated risk factors in a US Veterans Affairs population receiving ocular care services.

Design: Retrospective study.

Methods: settings: Patients were seen in the Miami and Broward Veterans Affairs eye clinics between 2005 and 2010.

Validation of a photographic vitreous haze grading technique for clinical trials in uveitis.

Purpose: To validate a photographic vitreous haze grading technique using a 9-step logarithmic scale in patients enrolled in a randomized, controlled clinical trial in uveitis.

Design: Retrospective study of clinical trials methodology.

Setting: University-based department of ophthalmology.

Practice preferences for glaucoma surgery: a survey of the American Glaucoma Society in 2008.

Background And Objective: To evaluate glaucoma surgical practice patterns among members of the American Glaucoma Society (AGS).

Patients And Methods: An anonymous web-based survey was sent to AGS members to determine their preferred surgical approach in ten clinical settings. Survey results were compared with those from 1996 and 2002.

Practice preferences for glaucoma surgery: a survey of the american glaucoma society in 2008.

Background And Objective: To evaluate glaucoma surgical practice patterns among members of the American Glaucoma Society (AGS).

Patients And Methods: An anonymous web-based survey was sent to AGS members to determine their preferred surgical approach in ten clinical settings. Survey results were compared with those from 1996 and 2002.

Advanced retinoblastoma treatment: targeting hypoxia by inhibition of the mammalian target of rapamycin (mTOR) in LH(BETA)T(AG) retinal tumors.

Purpose: The purpose of this study is to analyze the dose response of the mammalian target of rapamycin (mTOR) inhibitor, rapamycin, on tumor burden and hypoxia, and study the treatment effect on vasculature in LH(BETA)T(AG) retinal tumors.

Methods: This study was approved by the Institutional Animal Care and Use Committee and follows Association for Research in Vision and Ophthalmology guidelines. Eighteen-week-old LH(BETA)T(AG) retinal tumor eyes (n = 30) were evaluated.

Primate lens capsule elasticity assessed using Atomic Force Microscopy.

The purpose of this project is to measure the elasticity of the human and non-human primate lens capsule at the microscopic scale using Atomic Force Microscopy (AFM). Elasticity measurements were performed using AFM on the excised anterior lens capsule from 9 cynomolgus monkey (5.9-8.

Spectral domain optical coherence tomography imaging of drusen in nonexudative age-related macular degeneration.

Purpose: To measure drusen area and volume in eyes with nonexudative age-related macular degeneration (AMD) using spectral domain optical coherence tomography imaging (SD-OCT).

Design: Evaluation of diagnostic technology.

Participants: One hundred three eyes from 74 patients with drusen.

Lack of association between glaucoma and macular choroidal thickness measured with enhanced depth-imaging optical coherence tomography.

Purpose: To compare choroidal thickness measurements among normal eyes, eyes with normal tension glaucoma (NTG), and those with primary open-angle glaucoma (POAG), and to correlate choroidal thickness with demographic and clinical ocular parameters.

Methods: Choroidal thickness was measured with enhanced depth-imaging (EDI) optical coherence tomography (OCT) in one eye of 38 normal, 20 NTG, and 56 POAG subjects and compared among groups. The mean age was 69.

Novel retinoblastoma treatment avoids chemotherapy: the effect of optimally timed combination therapy with angiogenic and glycolytic inhibitors on LH(BETA)T(AG) retinoblastoma tumors.

Purpose: The purpose of this study was to evaluate the effect of optimally timed combination treatment with angiogenic and glycolytic inhibitors on tumor burden, hypoxia, and angiogenesis in advanced retinoblastoma tumors.

Methods: LH(BETA)T(AG) mice (n =30) were evaluated. Mice were divided into 5 groups (n =6) and received injections at 16 weeks of age (advanced tumors) with a) saline, b) anecortave acetate (AA), c) 2-deoxyglucose (2-DG), d) AA +2-DG (1 day post-AA treatment), or e) AA +2-DG (1 week post-AA treatment).

Outcomes of birdshot chorioretinopathy treated with an intravitreal sustained-release fluocinolone acetonide-containing device.

Purpose: To evaluate outcomes in birdshot chorioretinopathy following intravitreal implantation of a fluocinolone acetonide-containing drug delivery device.

Design: Retrospective, multicenter, interventional case study.

Methods: University- and community-based tertiary care.

C57BL/6J, DBA/2J, and DBA/2J.Gpnmb mice have different visual signal processing in the inner retina.

Purpose: To characterize differences in retinal ganglion cell (RGC) function in mouse strains relevant to disease models. C57BL/6J (B6) and DBA/2J (D2) are the two most common mouse strains; D2 has two mutated genes, tyrosinase-related protein 1 (Tyrp1) and glycoprotein non-metastatic melanoma protein B (Gpnmb), causing iris disease and intraocular pressure (IOP) elevation after 6 months of age that results in RGC degeneration, and is the most widely used model of glaucoma. DBA/2J.

Quantification of change in axonal birefringence following surgical reduction in intraocular pressure.

Background And Objective: the purpose of this study was to examine the hypothesis that retinal nerve fiber layer (RNFL) birefringence increases following surgical reduction of intraocular pressure (IOP).

Patients And Methods: twenty-six glaucomatous eyes requiring trabeculectomy or drainage implant were enrolled. Optical coherence tomography (OCT), scanning laser polarimetry (SLP), and IOP measurements were performed preoperatively and 3 months postoperatively.

Progression of geographic atrophy in age-related macular degeneration imaged with spectral domain optical coherence tomography.

Purpose: To determine the area and enlargement rate (ER) of geographic atrophy (GA) in patients with age-related macular degeneration (AMD) using the spectral domain optical coherence tomography (SD-OCT) fundus image.

Design: Prospective, longitudinal, natural history study.

Participants: Eighty-six eyes of 64 patients with ≥6 months of follow-up.

Identification of Hnrph3 as an autoantigen for acute anterior uveitis.

Acute anterior uveitis (AAU) is the most common form of autoimmune uveitis in the eye with few known autoantigens. Identification of autoantigens will improve our understanding of the molecular mechanisms and capability for disease diagnosis. Phage display is a powerful technology for autoantigen identification.

Treatment outcomes in the Ahmed Baerveldt Comparison Study after 1 year of follow-up.

Purpose: To determine the relative efficacy and complications of the Ahmed glaucoma valve (AGV) model FP7 (New World Medical, Ranchos Cucamonga, CA) and the Baerveldt glaucoma implant (BGI) model 101-350 (Abbott Medical Optics, Abbott Park, IL) in refractory glaucoma.

Design: Multicenter, randomized, controlled clinical trial.

Participants: Two hundred seventy-six patients, including 143 in the AGV group and 133 in the BGI group.

The Ahmed Baerveldt Comparison Study methodology, baseline patient characteristics, and intraoperative complications.

Purpose: The Ahmed Baerveldt Comparison (ABC) Study compares the long-term outcomes and complications of the Ahmed glaucoma valve (AGV; model FP7; New World Medical, Los Ranchos, CA) and the Baerveldt glaucoma implant (BGI; model 101-350; Abbott Medical Optics, Abbott Park, IL).

Design: Multicenter, randomized, controlled clinical trial.

Participants: Two hundred seventy-six glaucoma patients at 16 clinical centers worldwide who were 18 to 85 years of age with inadequately controlled intraocular pressure (IOP; ≥18 mmHg) in whom placement of an aqueous shunt was planned.