MIBiG 4.0: advancing biosynthetic gene cluster curation through global collaboration.

Specialized or secondary metabolites are small molecules of biological origin, often showing potent biological activities with applications in agriculture, engineering and medicine. Usually, the biosynthesis of these natural products is governed by sets of co-regulated and physically clustered genes known as biosynthetic gene clusters (BGCs). To share information about BGCs in a standardized and machine-readable way, the Minimum Information about a Biosynthetic Gene cluster (MIBiG) data standard and repository was initiated in 2015.

Inaugural editorial for Journal of Counseling Psychology.

The Journal of Counseling Psychology serves as the premier journal for critical and rigorous research within the field and beyond. In their inaugural editorial for Journa, Liu is joined by their associated editors and inaugural JCP fellows who have agreed to share authorship and their positionalities. In considering the Journal of Counseling Psychology for research, the editors encourage authors to reflect on these positionalities and how they might integrate their own into their publications.

antiSMASH 7.0: new and improved predictions for detection, regulation, chemical structures and visualisation.

Microorganisms produce small bioactive compounds as part of their secondary or specialised metabolism. Often, such metabolites have antimicrobial, anticancer, antifungal, antiviral or other bio-activities and thus play an important role for applications in medicine and agriculture. In the past decade, genome mining has become a widely-used method to explore, access, and analyse the available biodiversity of these compounds.

Behavioral health services for urban American Indians and Alaska Natives: A thematic analysis of interviews with 10 program directors.

Urban Indian Health Programs (UIHPs) are one of the primary sources of government-funded health care for the millions of American Indian and Alaskan Native (AI/AN) people living in urban areas. The goal of this study is to better understand what services are available at UIHPs and how resources are being used to support these services. Semistructured interviews with behavioral health directors at 10 UIHPs were reported, transcribed, and thematically analyzed to address this knowledge gap.

Microarray-Based Screening of Putative HSP90 Inhibitors Predicted and Isolated from Microorganisms.

Protein microarrays are useful tools for detecting the presence of a target where different prey and bait combinations exist. Here we describe the extended application for a functional target-oriented screening assay with full length Heat shock proteins (HSPs ) for the identification of novel compounds.

Pursuing the Promise of Preschool: An Exploratory Investigation of the Perceptions of Parents Experiencing Homelessness.

Rates of homelessness are worsening in the United States, with a third of individuals experiencing homelessness being families with children. These families face many challenges, including limited social supports, insufficient access to services, and mental health concerns. These challenges inform a nuanced worldview, leading parents experiencing homelessness to understand their child's school life in unique ways.

Creating a process to standardize regimen order sets within an electronic health record.

Purpose: US Oncology uses regimen order sets in clinical practice to treat patients. However, the process to assure accuracy and upkeep of these order sets has not been described. The purpose of this project was to evaluate the regimens housed in the electronic health record, iKnowMed, to determine their appropriateness and accuracy.

Oscillations of a bose-einstein condensate rotating in a harmonic plus quartic trap.

We study the normal modes of a two-dimensional rotating Bose-Einstein condensate confined in a quadratic plus quartic trap. Hydrodynamic theory and sum rules are used to derive analytical predictions for the collective frequencies in the limit of high angular velocities Omega where the vortex lattice produced by the rotation exhibits an annular structure. We predict a class of excitations with frequency sqrt[6]Omega in the rotating frame, irrespective of the mode multipolarity m, as well as a class of low energy modes with frequency proportional to |m|/Omega.

Safety profile and tolerability of amprenavir in the treatment of adult and pediatric patients with HIV infection.

Background: Amprenavir (APV) is a new HIV-I protease inhibitor used in combination with other antiretroviral agents for the treatment of HIV-1 infection.

Objective: The aim of this study was to assess the safety profile and tolerability of APV.

Methods: A review of data from 358 adults enrolled in 2 phase III, randomized, 48-week, controlled studies and from 268 children enrolled in 1 phase II and 1 phase III study was conducted.

Anomalous modes drive vortex dynamics in confined Bose-Einstein condensates.

The dynamics of vortices in trapped Bose-Einstein condensates are investigated both analytically and numerically. In axially symmetric traps, the critical rotation frequency for metastability of an isolated vortex coincides with the largest vortex precession frequency (or anomalous mode) in the Bogoliubov excitation spectrum. The number of anomalous modes increases for an elongated condensate.

Stability of a vortex in a trapped Bose-Einstein condensate.

Based on the method of matched asymptotic expansions and on a time-dependent variational analysis, we study the dynamics of a vortex in a three-dimensional disk-shaped nonaxisymmetric condensate in the Thomas-Fermi limit. Both methods show that a vortex in a trapped Bose-Einstein condensate has formally unstable normal mode(s) with positive normalization and negative frequency, corresponding to a precession of the vortex line around the center of the trap. In a rotating trap, the solution becomes stable above an angular velocity Omega(m), characterizing the onset of metastability with respect to small transverse displacements of the vortex from the central axis.

A phase II safety and efficacy study of amprenavir in combination with zidovudine and lamivudine in HIV-infected patients with limited antiretroviral experience. Amprenavir PROAB2002 Study Team.

Objective: To determine the safety and efficacy of amprenavir (APV) in combination with lamivudine (3TC) and zidovudine (ZDV).

Design: Multicenter, randomized, partially blinded trial.

Setting: Nine study sites in the United States and Europe.

Asymptomatic oral Candida albicans carriage in HIV-infection: frequency and predisposing factors.

Many studies have focused on the epidemiology and pathogenesis of oral candidiasis in HIV infection. Little is known on the incidence and predisposing factors of asymptomatic oral candida carriage in this setting, obviously an important issue in view of prophylaxis. To address this question, 261 consecutive HIV-infected individuals without clinical evidence of candidiasis were investigated.

Proliferative pituitary lesions in rats treated with salmon or porcine calcitonin.

Calcitonin, the serum calcium-lowering hormone, has been used in the treatment of hypercalcemia of malignancy and postmenopausal osteoporosis in humans for several years without any adverse effects. Recent studies in rats have indicated that calcitonin may be associated with morphologic effects on the pituitary. A large study was performed on 2 strains of rats, Sprague-Dawley (SD) and Fischer-344 (F-344), with 2 types of calcitonin, salmon-derived (sCT) and porcine-derived (pCT) calcitonin to evaluate possible effects on the pituitary.