Publications by authors named "Festus Dogunro"
Background: Since its reemergence in 2017, yellow fever (YF) has been active in Nigeria. The Nigeria Centre for Disease Control (NCDC) has coordinated responses to the outbreaks with the support of the World Health Organization (WHO). The National Arbovirus and Vectors Research Centre (NAVRC) handles the vector component of these responses.
View Article and Find Full Text PDFThe emergence of varying levels of resistance to currently available antimalarial drugs significantly threatens global health. This factor heightens the urgency to explore bioactive compounds from natural products with a view to discovering and developing newer antimalarial drugs with novel mode of actions. Therefore, we evaluated the inhibitory effects of sixteen phytocompounds from leaf extract against drug targets such as circumsporozoite protein (PfCSP), merozoite surface protein 1 (PfMSP1) and erythrocyte membrane protein 1 (PfEMP1).
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- - Edo State experienced an outbreak of yellow fever from September to November 2018, prompting the Nigeria Centre for Disease Control to deploy a Rapid Response Team for investigation and management of the situation.
- - The investigation identified 209 suspected cases, with 67 confirmed cases, a case fatality rate of 22.4%, and highlighted low vaccination coverage among the population, particularly in children.
- - Findings indicated a significant risk of yellow fever transmission due to the presence of Aedes mosquitoes, leading to the implementation of a reactive mass vaccination campaign to control the outbreak.
Article Synopsis
- * This study utilized metagenomic sequencing to analyze mosquito samples collected from Yellow fever outbreaks in Nigeria between 2017 and 2020, focusing on Aedes and Anopheles species.
- * A total of seven distinct viruses were identified, expanding the understanding of insect-specific viruses (ISVs) and their potential link to pathogenic viruses, demonstrating the effectiveness of advanced sequencing technology in virology research.
Background: Progress made in the control of malaria vectors globally is largely due to the use of insecticides. However, success in the fight against malaria has slowed down or even stalled due to a host of factors including insecticide resistance. The greatest burden of the disease is felt in Africa, particularly Nigeria.
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