Pharmacokinetics and saliva secretion of paracetamol in healthy male Nigerians.

A preliminary pharmacokinetic study of paracetamol was carried out in Nigerians for whom it is normal to consume paracetamol or its combination during almost any type of symptoms. After a single oral dose of 1000 mg of the drug to eight adult male volunteers, paracetamol was measured in plasma and saliva using high-performance liquid chromatography. The plasma profile showed a biexponential decline after peak absorption.