Synopsis of recent research by authors named "Festo Dugange"
- Festo Dugange's research primarily focuses on the prevention of mother-to-child transmission (PMTCT) of HIV in Tanzania, examining the effectiveness and safety of various antiretroviral regimens, especially the impact of zidovudine (AZT).
- Significant findings include the emergence of drug-resistant HIV-1 variants in women undergoing triple antiretroviral prophylaxis and the associated hematological changes in both mothers and infants exposed to AZT, highlighting the complexities of medication adherence and potential drug toxicities.
- The studies utilize advanced methodologies such as ultra-deep sequencing and real-time PCR to detect minor drug-resistant variants, thus contributing valuable insights into the challenges faced in resource-limited settings regarding HIV treatment and prevention strategies.
