Publications by authors named "Feryal H Alharthy"
Docosahexaenoic acid (DHA) is an omega-3 polyunsaturated fatty acid with promising anticancer potential. Anaemia is a frequent adverse effect of anticancer treatment caused in part by eryptosis and haemolysis. Thus, it is important to investigate the role of DHA in red blood cell (RBC) death.
View Article and Find Full Text PDFArticle Synopsis
- Anticancer medications can lead to anemia through processes like hemolysis (destruction of red blood cells) and eryptosis (programmed cell death of RBCs), but the specific mechanisms are not well understood.
- α-Linolenic acid (ALA) shows anticancer potential, yet its effects on red blood cell physiology were unclear until this study exposed healthy RBCs to various concentrations of ALA and analyzed hemolysis, AChE activity, and cell stress responses.
- The results indicate that ALA increases hemolysis and eryptosis in a dose-dependent manner, likely due to calcium buildup, oxidative stress, and other cellular changes, suggesting that using certain inhibitors may reduce ALA