Publications by authors named "Ferry de Klein"
J Innate Immun
December 2023
Article Synopsis
- Nerve damage activates the complement system, leading to the formation of the membrane attack complex (MAC), which impairs recovery in the peripheral nervous system.
- A new monoclonal antibody, CP010, has been developed to target and inhibit the complement component C6, preventing MAC formation and enhancing recovery after nerve injury.
- In tests with transgenic rats, CP010 showed promising results in preventing diseases like experimental autoimmune myasthenia gravis and reducing relapse in encephalomyelitis, suggesting its potential as a therapeutic treatment for neuronal conditions.
