The continued evolution of severe acute respiratory syndrome 2 (SARS-CoV-2) requires persistent monitoring of its subvariants. Omicron subvariants are responsible for the vast majority of SARS-CoV-2 infections worldwide, with XBB and BA.2.
View Article and Find Full Text PDFThe severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) spike glycoprotein (S) binds to angiotensin-converting enzyme 2 (ACE2) to mediate membrane fusion via two distinct pathways: 1) a surface, serine protease-dependent or 2) an endosomal, cysteine protease-dependent pathway. In this study, we found that SARS-CoV-2 S has a wider protease usage and can also be activated by TMPRSS13 and matrix metalloproteinases (MMPs). We found that MMP-2 and MMP-9 played roles in SARS-CoV-2 S cell-cell fusion and TMPRSS2- and cathepsin-independent viral entry in cells expressing high MMP levels.
View Article and Find Full Text PDFA new three-phase therapeutical approach to retained biliary stones (RBS) is designed to shorten the long treatment times with Monooctanoin (Mo). In the first phase, the litholytic agent is infused to soften the stones. In the second one the calculi are crushed, and in the last complete elimination of the fragmentary stones into the duodenum is obtained after 1-2 flushings with ceruletide.
View Article and Find Full Text PDFMinerva Dietol Gastroenterol
February 1987
Minerva Med
September 1984
The Authors report about their experience of 27 cases of Total Enteral Feeding. The role of the nitrogen balance inversion, from negative to positive, as an expression of protein anabolism, is specially emphasized. This parameter proves more suitable than the serum albumin level increase, of low statistical significance.
View Article and Find Full Text PDFBarium peritonites are known to be a serious complication of barium enema examinations, being accompanied by a high mortality rate. The authors made their study injecting barium and radioactive 133Ba in the peritoneum of 68 rats without causing damages to the colon, in order to verify the toxicity of barium if injected in the peritoneum, and to evaluate the various extraperitoneal locations. Moreover, they compared the alterations caused by this agent with those consequent to a similar agent, such as talcum.
View Article and Find Full Text PDFMinerva Dietol Gastroenterol
June 1981
Preliminary experiments in extracorporeal cleansing of long ischaemic limbs with isolated liver prior to re-establishment of normal circulation are described. The absence of cases of renal block and the survival of all the animals so treated offer encouragement for the prosecution of this line of investigation.
View Article and Find Full Text PDFPersonal experience with 131I-Hippuran nephrography, particularly in surgical cases, is described. The examination is a useful aid to the diagnosis diagnosis of recent colic and in the investigation of cases where a negative finding has been obtained with other radiological means. Its pre- and post-operative employment in the evaluation of renal function is also discussed.
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