Diabetes Remission After Bariatric Surgery: A 10-Year Follow-Up Study.

Introduction: Treatment of type 2 diabetes (T2DM) in patients with obesity can be challenging. Metabolic and bariatric surgery (MBS) has shown promising results in improving glycemic control and even achieving remission in T2DM patients with obesity. However, the durability of glycemic improvements in T2DM patients following MBS remains insufficiently studied.

Protein and Oil Contents, Micro- and Macronutrients, and Other Quality Indicators of Soybean Cultivated in Lowland Fields.

The cultivation of soybean is being expanded in traditional areas cultivated with rice, called the lowlands. However, soil characteristics are different from those in the highlands, which influences the exportation of nutrients to the grains. Therefore, this study aimed to determine the physical-chemical and technological characteristics of soybean grains harvested in lowlands in Brazil.

Morbidity associated with schistosomiasis in adult population of Chókwè district, Mozambique.

Background: Mozambique is one of the countries with the highest prevalence of schistosomiasis, although there is little data on the prevalence of disease and associated morbidity in the adult population. This study aimed to describe and characterize the morbidity associated with schistosomiasis in the adult population of Chókwè district and to explore the use of anamnestic questionnaires and urine dipsticks, as well as point-of-care ultrasound for urinary related findings, to better characterize disease prevalence and morbidity.

Methodology: Between April and October 2018, we conducted a cross-sectional study embedded within the Chókwè Health Research and Training Centre.

Early-life IL-4 administration induces long-term changes in microglia in the cerebellum and prefrontal cortex.

Microglia are crucial for brain development and their function can be impacted by postnatal insults, such as early-life allergies. These are characterized by an upregulation of interleukin (IL)-4 levels. Allergies share a strong comorbidity with Autism Spectrum Disorders (ASD) and Attention-Deficit/Hyperactivity Disorder (ADHD).

Nanocompression of 20 nm Silver Nanoparticles: In situ Aberration-Corrected TEM and Atomistic Simulations.

Single-crystalline nanoparticles play an increasingly important role in a wide variety of fields including pharmaceuticals, advanced materials, catalysts for fuel cells, energy materials, as well as environmental detection and monitoring. Yet, the deformation mechanisms of very small nanoparticles are still poorly understood, in particular the role played by single dislocations and their interaction with surfaces. In this work, silver nanoparticles with particularly small dimensions (≈20 nanometers in diameter) are compressed in situ in an aberration-corrected transmission electron microscopy (TEM) and molecular dynamics (MD) simulations.

Defining core competencies for telehealth in healthcare higher education: A Delphi study.

Background: While technology brings many opportunities for optimizing and improving health services, the lack of professionals trained in telehealth poses an important obstacle. Despite the existance of core competency frameworks for some healthcare professions, there is currently no consensus or guidelines on the core competencies that telehealth professionals should possess within the context of a higher education curriculum. This can hinder the potential benefits of healthcare service delivery.

Vascular and inflammatory biomarkers of cardiovascular events in non-steroidal anti-inflammatory drug users.

Aims: The Standard care vs. Celecoxib Outcome Trial (SCOT) found similar risk of cardiovascular events with traditional non-steroidal anti-inflammatory drugs (NSAIDs) and the cyclooxygenase-2-selective drug celecoxib. While pre-clinical work has suggested roles for vascular and renal dysfunction in NSAID cardiovascular toxicity, our understanding of these mechanisms remains incomplete.

Cross-cultural adaptation of the Karnofsky Performance Status instrument to Brazilian Portuguese.

Introduction: The Karnofsky Performance Status (KPS) is one of the most widely used tools for assessing the prognosis of oncology patients, providing an estimate of treatment efficiency and survival. Despite this, it is commonly used in free translations without validation. The objective of the present study was to perform the cross-cultural adaptation of the KPS instrument to Brazilian Portuguese (KPS-BR) through the stages of conceptual, semantic, operational, measurement, and functional equivalences.

An Innovative Intervention Model for Children and Young People in Residential Care: The D'ART-TE Project.

(1) Background: Residential care (RC) for children and youth should provide a holistic experience of growing up. Currently, RC homes face many challenges, highlighting the need for validated, innovative interventions. D'AR-TE is a pilot project aimed at creating an innovative intervention model for children and youth in RC, promoting protective factors through activities designed to enhance personal skills, socialization, and relationship building.

Systemic acupuncture application does not change muscle performance parameters in women: A randomized, controlled, double-blind pilot study.

Background/objective: Acupuncture is used for therapeutic purposes. The possible beneficial role of this therapy may be as an ergogenic resource for the performance of fitness variables in exercise and sports. To date, acupuncture has been associated with increases in muscle strength, aerobic power, and vertical jump performance, but the evidence is still inconclusive.

Acute effects of systemic acupuncture treatment on strength and power performance of male handball players - A double blinded randomized controlled trial.

Objective: The purpose of this investigation was to evaluate the acute effects of a systemic acupuncture protocol on strength and power performance of male handball players.

Introduction: Regarding sports performance, different strategies have been used displaying different outcomes. In a more holistic approach, the use of manual therapies such as acupuncture has gained increased attention.

Repositioning anthelmintics for the treatment of inflammatory-based pathological conditions.

Acute, uncontrolled and/or long-lasting inflammation causes a breakdown in immunological tolerance, leading to chronicity and contributing to a series of significant local or systemic tissue changes. Anti-inflammatory efficacy, fewer adverse effects, improved selectivity, and curative action are imminent issues for patients suffering from chronic inflammation-related pathologies. Then, we performed a complete and critical review about anthelmintics, discussing the main classes and the available preclinical evidence on repurposing to treat inflammation-based conditions.

Impact of Regulatory Risk Communication on Thrombosis With Thrombocytopenia Syndrome for COVID-19 Adenovirus Vector Vaccines on European Healthcare Professionals.

Purpose: The European Medicines Agency (EMA) issued regulatory actions and communications in 2021 on thrombosis with thrombocytopenia syndrome (TTS) associated with adenovirus vector vaccines Vaxzevria or Jcovden. This study aimed to evaluate the impact of these actions on awareness, knowledge and implementation in practises of healthcare professionals (HCP).

Methods: Web-based cross-sectional surveys were conducted on HCPs engaged in the vaccination, monitoring or counselling about the vaccines.

Tree cover and palm population structure determine patterns of palm-pollinator interaction networks in a grassland-forest ecotone.

Pollen dispersal by insects determines the patterns of reproductive encounters between plants with flowers that have spatially or temporally segregated sexes. Pollinators exhibit varied responses to environmental gradients, such as those in grassland-forest ecotones. Individual-based interaction networks are useful yet underexplored tools to understand how interactions vary across these gradients.

Resistance intensity test (RIT): a novel bioassay for quantifying the level of acaricide resistance in Rhipicephalus microplus ticks.

Background: One bioassay for detecting acaricide resistance in livestock ticks is the adult immersion test (AIT), wherein engorged ticks are briefly immersed into a solution of a particular acaricidal compound and examined for mortality, their egg-laying capacity and offspring hatchability in vitro. Usually, the recommended label dose or an established discriminating dose of an acaricide is used to determine high mortality (≥ 95%) of susceptible tick strains. Such a test intends to detect the presence of resistance in a tick population.

APAtizer: a tool for alternative polyadenylation analysis of RNA-Seq data.

Summary: APAtizer is a tool designed to analyze alternative polyadenylation events on RNA-sequencing data. The tool handles different file formats, including BAM, htseq, and DaPars bedGraph files. It provides a user-friendly interface that allows users to generate informative visualizations, including Volcano plots, heatmaps, and gene lists.

Relative sparing of dopaminergic terminals in the caudate nucleus is a feature of rest tremor in Parkinson's disease.

Resting tremor (RT) is a Parkinson's disease (PD) symptom with an unclear relationship to the dopaminergic system. We analysed data from 432 subjects from the Parkinson's Progression Markers Initiative, 57 additional PD patients and controls and 86 subjects referred for dopamine transporter single-photon emission computed tomography (DaT-SPECT). Caudate binding ratio (CBR), but not putamen binding ratio, was higher in RT patients.

The effects of different doses of single- and dual-wavelength whole-body photobiomodulation on metabolic parameters in obese mice.

Photobiomodulation (PBM) shows beneficial effects on obesity-related alterations. It is not known if dual- is more beneficial than single-wavelength, nor the dose-response effect of such treatments. The effects of different doses of single- and dual-wavelength whole-body PBM on metabolic parameters in obese mice were evaluated.

"I stayed on the street, as if there was no COVID-19": enacting practices of care with youth at risk of violence and social exclusion in Portugal.

As the COVID-19 pandemic unfolded, a world of carelessness was made visible. Public health guidelines against the spread of COVID-19 (e.g.

Ascorbic acid regulates and toxicogenetic effects of hydroxyurea on eukaryotic cells.

Hydroxyurea (HU) exerts unique and diverse biological effects as an anti-leukemic agent, irradiation sensitizer, and HbS inducer in patients with sickle cell anemia. Herein, we assessed the potential toxicogenic and/or oxidant effects of hydroxyurea associated with ascorbic acid by examinations in and human cancer cells and systemically on mice tissues. Growing roots and HCT-116 colorectal tumor cells were examined after HU and HU plus ascorbic acid exposure.